2odr

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{{STRUCTURE_2odr| PDB=2odr | SCENE= }}
{{STRUCTURE_2odr| PDB=2odr | SCENE= }}
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'''Methanococcus Maripaludis Phosphoseryl-tRNA synthetase'''
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===Methanococcus Maripaludis Phosphoseryl-tRNA synthetase===
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==Overview==
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A number of archaeal organisms generate Cys-tRNA(Cys) in a two-step pathway, first charging phosphoserine (Sep) onto tRNA(Cys) and subsequently converting it to Cys-tRNA(Cys). We have determined, at 3.2-A resolution, the structure of the Methanococcus maripaludis phosphoseryl-tRNA synthetase (SepRS), which catalyzes the first step of this pathway. The structure shows that SepRS is a class II, alpha(4) synthetase whose quaternary structure arrangement of subunits closely resembles that of the heterotetrameric (alphabeta)(2) phenylalanyl-tRNA synthetase (PheRS). Homology modeling of a tRNA complex indicates that, in contrast to PheRS, a single monomer in the SepRS tetramer may recognize both the acceptor terminus and anticodon of a tRNA substrate. Using a complex with tungstate as a marker for the position of the phosphate moiety of Sep, we suggest that SepRS and PheRS bind their respective amino acid substrates in dissimilar orientations by using different residues.
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{{ABSTRACT_PUBMED_17301225}}
==About this Structure==
==About this Structure==
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[[Category: Steitz, T A.]]
[[Category: Steitz, T A.]]
[[Category: Phosphoserine trna synthetase class ii]]
[[Category: Phosphoserine trna synthetase class ii]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 10:41:42 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 06:46:57 2008''

Revision as of 03:47, 28 July 2008

Image:2odr.png

Template:STRUCTURE 2odr

Methanococcus Maripaludis Phosphoseryl-tRNA synthetase

Template:ABSTRACT PUBMED 17301225

About this Structure

2ODR is a Protein complex structure of sequences from Methanococcus maripaludis. Full crystallographic information is available from OCA.

Reference

Toward understanding phosphoseryl-tRNACys formation: the crystal structure of Methanococcus maripaludis phosphoseryl-tRNA synthetase., Kamtekar S, Hohn MJ, Park HS, Schnitzbauer M, Sauerwald A, Soll D, Steitz TA, Proc Natl Acad Sci U S A. 2007 Feb 20;104(8):2620-5. Epub 2007 Feb 14. PMID:17301225

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