1z2w

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[[Image:1z2w.gif|left|200px]]
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{{Seed}}
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[[Image:1z2w.png|left|200px]]
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{{STRUCTURE_1z2w| PDB=1z2w | SCENE= }}
{{STRUCTURE_1z2w| PDB=1z2w | SCENE= }}
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'''Crystal structure of mouse Vps29 complexed with Mn2+'''
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===Crystal structure of mouse Vps29 complexed with Mn2+===
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==Overview==
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The retromer complex is responsible for the retrieval of mannose 6-phosphate receptors from the endosomal system to the Golgi. Here we present the crystal structure of the mammalian retromer subunit mVps29 and show that it has structural similarity to divalent metal-containing phosphoesterases. mVps29 can coordinate metals in a similar manner but has no detectable phosphoesterase activity in vitro, suggesting a unique specificity or function. The mVps29 and mVps26 subunits bind independently to mVps35 and together form a high-affinity heterotrimeric subcomplex. Mutagenesis reveals the structural basis for the interaction of mVps29 with mVps35 and subsequent association with endosomal membranes in vivo. A conserved hydrophobic surface distinct from the primary Vps35p binding site mediates assembly of the Vps29p-Vps26p-Vps35p subcomplex with sorting nexins in yeast, and mutation of either site results in a defect in retromer-dependent membrane trafficking.
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(as it appears on PubMed at http://www.pubmed.gov), where 15965486 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15965486}}
==About this Structure==
==About this Structure==
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[[Category: Retromer]]
[[Category: Retromer]]
[[Category: Vps29]]
[[Category: Vps29]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 17:07:11 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 06:48:28 2008''

Revision as of 03:48, 28 July 2008

Image:1z2w.png

Template:STRUCTURE 1z2w

Crystal structure of mouse Vps29 complexed with Mn2+

Template:ABSTRACT PUBMED 15965486

About this Structure

1Z2W is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

Vps29 has a phosphoesterase fold that acts as a protein interaction scaffold for retromer assembly., Collins BM, Skinner CF, Watson PJ, Seaman MN, Owen DJ, Nat Struct Mol Biol. 2005 Jul;12(7):594-602. Epub 2005 Jun 19. PMID:15965486

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