2f16

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{{STRUCTURE_2f16| PDB=2f16 | SCENE= }}
{{STRUCTURE_2f16| PDB=2f16 | SCENE= }}
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'''Crystal structure of the yeast 20S proteasome in complex with bortezomib'''
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===Crystal structure of the yeast 20S proteasome in complex with bortezomib===
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==Overview==
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The dipeptide boronic acid bortezomib, also termed VELCADE, is a proteasome inhibitor now in use for the treatment of multiple myeloma, and its use for the treatment of other malignancies is being explored. We determined the crystal structure of the yeast 20S proteasome in complex with bortezomib to establish the specificity and binding mode of bortezomib to the proteasome's different catalytically active sites. This structure should enable the rational design of new boronic acid derivatives with improved affinities and specificities for individual active subunits.
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(as it appears on PubMed at http://www.pubmed.gov), where 16531229 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16531229}}
==About this Structure==
==About this Structure==
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[[Category: Complex structure covalently bound to the synthetic inihibtor bortezomib]]
[[Category: Complex structure covalently bound to the synthetic inihibtor bortezomib]]
[[Category: Hydrolase]]
[[Category: Hydrolase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jun 5 10:00:52 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 06:50:27 2008''

Revision as of 03:50, 28 July 2008

Image:2f16.png

Template:STRUCTURE 2f16

Crystal structure of the yeast 20S proteasome in complex with bortezomib

Template:ABSTRACT PUBMED 16531229

About this Structure

2F16 is a Protein complex structure of sequences from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Crystal structure of the boronic acid-based proteasome inhibitor bortezomib in complex with the yeast 20S proteasome., Groll M, Berkers CR, Ploegh HL, Ovaa H, Structure. 2006 Mar;14(3):451-6. PMID:16531229

Page seeded by OCA on Mon Jul 28 06:50:27 2008

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