2uv1

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[[Image:2uv1.gif|left|200px]]
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{{STRUCTURE_2uv1| PDB=2uv1 | SCENE= }}
{{STRUCTURE_2uv1| PDB=2uv1 | SCENE= }}
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'''HEXAGONAL CRYSTAL FORM OF GAMS FROM BACTERIOPHAGE LAMBDA.'''
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===HEXAGONAL CRYSTAL FORM OF GAMS FROM BACTERIOPHAGE LAMBDA.===
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==Overview==
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In Escherichia coli, RecBCD processes double-stranded DNA breaks during the initial stages of homologous recombination. RecBCD contains helicase and nuclease activities, and unwinds and digests the blunt-ended DNA until a specific eight-nucleotide sequence, Chi, is encountered. Chi modulates the nuclease activity of RecBCD and results in a resected DNA end, which is a substrate for RecA during subsequent steps in recombination. RecBCD also acts as a defence mechanism against bacteriophage infection by digesting linear viral DNA present during virus replication or resulting from the action of restriction endonucleases. To avoid this fate, bacteriophage lambda encodes the gene Gam whose product is an inhibitor of RecBCD. Gam has been shown to bind to RecBCD and inhibit its helicase and nuclease activities. We show that Gam inhibits RecBCD by preventing it from binding DNA. We have solved the crystal structure of Gam from two different crystal forms. Using the published crystal structure of RecBCD in complex with DNA we suggest models for the molecular mechanism of Gam-mediated inhibition of RecBCD. We also propose that Gam could be a mimetic of single-stranded, and perhaps also double-stranded, DNA.
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(as it appears on PubMed at http://www.pubmed.gov), where 17544443 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17544443}}
==About this Structure==
==About this Structure==
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[[Category: Nuclease inhibitor recbcd inhibitor]]
[[Category: Nuclease inhibitor recbcd inhibitor]]
[[Category: Putative dna mimetic]]
[[Category: Putative dna mimetic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 17:32:41 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 06:51:36 2008''

Revision as of 03:51, 28 July 2008

Image:2uv1.png

Template:STRUCTURE 2uv1

HEXAGONAL CRYSTAL FORM OF GAMS FROM BACTERIOPHAGE LAMBDA.

Template:ABSTRACT PUBMED 17544443

About this Structure

2UV1 is a Single protein structure of sequence from Enterobacteria phage lambda. Full crystallographic information is available from OCA.

Reference

The crystal structure of lambda-Gam protein suggests a model for RecBCD inhibition., Court R, Cook N, Saikrishnan K, Wigley D, J Mol Biol. 2007 Aug 3;371(1):25-33. Epub 2007 May 18. PMID:17544443

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