2atw

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[[Image:2atw.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_2atw| PDB=2atw | SCENE= }}
{{STRUCTURE_2atw| PDB=2atw | SCENE= }}
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'''Structure of a Mycobacterium tuberculosis NusA-RNA complex'''
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===Structure of a Mycobacterium tuberculosis NusA-RNA complex===
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==Overview==
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NusA is a key regulator of bacterial transcriptional elongation, pausing, termination and antitermination, yet relatively little is known about the molecular basis of its activity in these fundamental processes. In Mycobacterium tuberculosis, NusA has been shown to bind with high affinity and specificity to BoxB-BoxA-BoxC antitermination sequences within the leader region of the single ribosomal RNA (rRNA) operon. We have determined high-resolution X-ray structures of a complex of NusA with two short oligo-ribonucleotides derived from the BoxC stem-loop motif and have characterised the interaction of NusA with a variety of RNAs derived from the antitermination region. These structures reveal the RNA bound in an extended conformation to a large interacting surface on both KH domains. Combining structural data with observed spectral and calorimetric changes, we now show that NusA binding destabilises secondary structure within rRNA antitermination sequences and propose a model where NusA functions as a chaperone for nascently forming RNA structures.
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The line below this paragraph, {{ABSTRACT_PUBMED_16193062}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 16193062 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16193062}}
==About this Structure==
==About this Structure==
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[[Category: Taylor, I A.]]
[[Category: Taylor, I A.]]
[[Category: Protein-rna complex]]
[[Category: Protein-rna complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 19:28:13 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 06:52:36 2008''

Revision as of 03:52, 28 July 2008

Image:2atw.png

Template:STRUCTURE 2atw

Structure of a Mycobacterium tuberculosis NusA-RNA complex

Template:ABSTRACT PUBMED 16193062

About this Structure

2ATW is a Single protein structure of sequence from Mycobacterium tuberculosis. Full crystallographic information is available from OCA.

Reference

Structure of a Mycobacterium tuberculosis NusA-RNA complex., Beuth B, Pennell S, Arnvig KB, Martin SR, Taylor IA, EMBO J. 2005 Oct 19;24(20):3576-87. Epub 2005 Sep 29. PMID:16193062

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