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1ow0

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{{STRUCTURE_1ow0| PDB=1ow0 | SCENE= }}
{{STRUCTURE_1ow0| PDB=1ow0 | SCENE= }}
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'''Crystal structure of human FcaRI bound to IgA1-Fc'''
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===Crystal structure of human FcaRI bound to IgA1-Fc===
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==Overview==
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Immunoglobulin-alpha (IgA)-bound antigens induce immune effector responses by activating the IgA-specific receptor FcalphaRI (CD89) on immune cells. Here we present crystal structures of human FcalphaRI alone and in a complex with the Fc region of IgA1 (Fcalpha). FcalphaRI has two immunoglobulin-like domains that are oriented at approximately right angles to each other. Fcalpha resembles the Fcs of immunoglobulins IgG and IgE, but has differently located interchain disulphide bonds and external rather than interdomain N-linked carbohydrates. Unlike 1:1 FcgammaRIII:IgG and Fc epsilon RI:IgE complexes, two FcalphaRI molecules bind each Fcalpha dimer, one at each Calpha2-Calpha3 junction. The FcalphaRI-binding site on IgA1 overlaps the reported polymeric immunoglobulin receptor (pIgR)-binding site, which might explain why secretory IgA cannot initiate phagocytosis or bind to FcalphaRI-expressing cells in the absence of an integrin co-receptor.
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The line below this paragraph, {{ABSTRACT_PUBMED_12768205}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 12768205 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12768205}}
==About this Structure==
==About this Structure==
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[[Category: Iga1]]
[[Category: Iga1]]
[[Category: Immunoglobulin-like domain]]
[[Category: Immunoglobulin-like domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:20:35 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 06:53:35 2008''

Revision as of 03:53, 28 July 2008

Image:1ow0.png

Template:STRUCTURE 1ow0

Crystal structure of human FcaRI bound to IgA1-Fc

Template:ABSTRACT PUBMED 12768205

About this Structure

1OW0 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Insights into IgA-mediated immune responses from the crystal structures of human FcalphaRI and its complex with IgA1-Fc., Herr AB, Ballister ER, Bjorkman PJ, Nature. 2003 Jun 5;423(6940):614-20. Epub 2003 May 21. PMID:12768205

Page seeded by OCA on Mon Jul 28 06:53:35 2008

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