1qd9

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{{STRUCTURE_1qd9| PDB=1qd9 | SCENE= }}
{{STRUCTURE_1qd9| PDB=1qd9 | SCENE= }}
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'''Bacillus subtilis YABJ'''
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===Bacillus subtilis YABJ===
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==Overview==
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The yabJ gene in Bacillus subtilis is required for adenine-mediated repression of purine biosynthetic genes in vivo and codes for an acid-soluble, 14-kDa protein. The molecular mechanism of YabJ is unknown. YabJ is a member of a large, widely distributed family of proteins of unknown biochemical function. The 1.7-A crystal structure of YabJ reveals a trimeric organization with extensive buried hydrophobic surface and an internal water-filled cavity. The most important finding in the structure is a deep, narrow cleft between subunits lined with nine side chains that are invariant among the 25 most similar homologs. This conserved site is proposed to be a binding or catalytic site for a ligand or substrate that is common to YabJ and other members of the YER057c/YjgF/UK114 family of proteins.
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{{ABSTRACT_PUBMED_10557275}}
==About this Structure==
==About this Structure==
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[[Category: Purine regulation]]
[[Category: Purine regulation]]
[[Category: Yjgf/yer057c family]]
[[Category: Yjgf/yer057c family]]
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Revision as of 03:54, 28 July 2008

Image:1qd9.png

Template:STRUCTURE 1qd9

Bacillus subtilis YABJ

Template:ABSTRACT PUBMED 10557275

About this Structure

1QD9 is a Single protein structure of sequence from Bacillus subtilis. Full crystallographic information is available from OCA.

Reference

Crystal structure of Bacillus subtilis YabJ, a purine regulatory protein and member of the highly conserved YjgF family., Sinha S, Rappu P, Lange SC, Mantsala P, Zalkin H, Smith JL, Proc Natl Acad Sci U S A. 1999 Nov 9;96(23):13074-9. PMID:10557275

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