1ygo

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[[Image:1ygo.gif|left|200px]]
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{{STRUCTURE_1ygo| PDB=1ygo | SCENE= }}
{{STRUCTURE_1ygo| PDB=1ygo | SCENE= }}
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'''Solution Structure of the pelle Death Domain'''
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===Solution Structure of the pelle Death Domain===
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==Overview==
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The interaction between the death domains (DDs) of Tube and the protein kinase Pelle is an important component of the Toll pathway. Published crystallographic data suggests that the Pelle-Tube DD interface is plastic and implies that in addition to the two predominant Pelle-Tube interfaces, a third interaction is possible. We present the NMR solution structure of the isolated death domain of Pelle and a study of the interaction between the DDs of Pelle and Tube. Our data suggests the solution structure of the isolated Pelle DD is similar to that of Pelle DD in complex with Tube. Additionally, they suggest that the plasticity observed in the crystal structure may not be relevant in the functioning death domain complex.
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{{ABSTRACT_PUBMED_16004997}}
==About this Structure==
==About this Structure==
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1YGO is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YGO OCA].
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1YGO is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YGO OCA].
==Reference==
==Reference==
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[[Category: Stott, K M.]]
[[Category: Stott, K M.]]
[[Category: Anti-parallel 6 helix bundle]]
[[Category: Anti-parallel 6 helix bundle]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 16:17:37 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 06:55:55 2008''

Revision as of 03:56, 28 July 2008

Image:1ygo.png

Template:STRUCTURE 1ygo

Solution Structure of the pelle Death Domain

Template:ABSTRACT PUBMED 16004997

About this Structure

1YGO is a Single protein structure of sequence from Drosophila melanogaster. Full experimental information is available from OCA.

Reference

Solution structure of the isolated Pelle death domain., Moncrieffe MC, Stott KM, Gay NJ, FEBS Lett. 2005 Jul 18;579(18):3920-6. PMID:16004997

Page seeded by OCA on Mon Jul 28 06:55:55 2008

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