2qk2

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{{STRUCTURE_2qk2| PDB=2qk2 | SCENE= }}
{{STRUCTURE_2qk2| PDB=2qk2 | SCENE= }}
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'''Structural Basis of Microtubule Plus End Tracking by XMAP215, CLIP-170 and EB1'''
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===Structural Basis of Microtubule Plus End Tracking by XMAP215, CLIP-170 and EB1===
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==Overview==
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Microtubule plus end binding proteins (+TIPs) localize to the dynamic plus ends of microtubules, where they stimulate microtubule growth and recruit signaling molecules. Three main +TIP classes have been identified (XMAP215, EB1, and CLIP-170), but whether they act upon microtubule plus ends through a similar mechanism has not been resolved. Here, we report crystal structures of the tubulin binding domains of XMAP215 (yeast Stu2p and Drosophila Msps), EB1 (yeast Bim1p and human EB1), and CLIP-170 (human), which reveal diverse tubulin binding interfaces. Functional studies, however, reveal a common property that native or artificial dimerization of tubulin binding domains (including chemically induced heterodimers of EB1 and CLIP-170) induces tubulin nucleation/assembly in vitro and, in most cases, plus end tracking in living cells. We propose that +TIPs, although diverse in structure, share a common property of multimerizing tubulin, thus acting as polymerization chaperones that aid in subunit addition to the microtubule plus end.
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{{ABSTRACT_PUBMED_17889670}}
==About this Structure==
==About this Structure==
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[[Category: Stu2]]
[[Category: Stu2]]
[[Category: Xmap215]]
[[Category: Xmap215]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 15:05:48 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 06:57:26 2008''

Revision as of 03:57, 28 July 2008

Image:2qk2.png

Template:STRUCTURE 2qk2

Structural Basis of Microtubule Plus End Tracking by XMAP215, CLIP-170 and EB1

Template:ABSTRACT PUBMED 17889670

About this Structure

2QK2 is a Single protein structure of sequence from Drosophila melanogaster. Full crystallographic information is available from OCA.

Reference

Structural basis of microtubule plus end tracking by XMAP215, CLIP-170, and EB1., Slep KC, Vale RD, Mol Cell. 2007 Sep 21;27(6):976-91. PMID:17889670

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