1yqk

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[[Image:1yqk.gif|left|200px]]
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{{Seed}}
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[[Image:1yqk.png|left|200px]]
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{{STRUCTURE_1yqk| PDB=1yqk | SCENE= }}
{{STRUCTURE_1yqk| PDB=1yqk | SCENE= }}
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'''Human 8-oxoguanine glycosylase crosslinked with guanine containing DNA'''
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===Human 8-oxoguanine glycosylase crosslinked with guanine containing DNA===
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==Overview==
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How DNA repair proteins distinguish between the rare sites of damage and the vast expanse of normal DNA is poorly understood. Recognizing the mutagenic lesion 8-oxoguanine (oxoG) represents an especially formidable challenge, because this oxidized nucleobase differs by only two atoms from its normal counterpart, guanine (G). Here we report the use of a covalent trapping strategy to capture a human oxoG repair protein, 8-oxoguanine DNA glycosylase I (hOGG1), in the act of interrogating normal DNA. The X-ray structure of the trapped complex features a target G nucleobase extruded from the DNA helix but denied insertion into the lesion recognition pocket of the enzyme. Free energy difference calculations show that both attractive and repulsive interactions have an important role in the preferential binding of oxoG compared with G to the active site. The structure reveals a remarkably effective gate-keeping strategy for lesion discrimination and suggests a mechanism for oxoG insertion into the hOGG1 active site.
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The line below this paragraph, {{ABSTRACT_PUBMED_15800616}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15800616 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15800616}}
==Disease==
==Disease==
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[[Category: Dna glycosylase]]
[[Category: Dna glycosylase]]
[[Category: Undamaged dna]]
[[Category: Undamaged dna]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 16:39:17 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 07:00:06 2008''

Revision as of 04:00, 28 July 2008

Image:1yqk.png

Template:STRUCTURE 1yqk

Contents

Human 8-oxoguanine glycosylase crosslinked with guanine containing DNA

Template:ABSTRACT PUBMED 15800616

Disease

Known disease associated with this structure: Renal cell carcinoma, clear cell, somatic OMIM:[601982]

About this Structure

1YQK is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of a repair enzyme interrogating undamaged DNA elucidates recognition of damaged DNA., Banerjee A, Yang W, Karplus M, Verdine GL, Nature. 2005 Mar 31;434(7033):612-8. PMID:15800616

Page seeded by OCA on Mon Jul 28 07:00:06 2008

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