1r02

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[[Image:1r02.gif|left|200px]]
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{{Seed}}
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[[Image:1r02.png|left|200px]]
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{{STRUCTURE_1r02| PDB=1r02 | SCENE= }}
{{STRUCTURE_1r02| PDB=1r02 | SCENE= }}
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'''Solution structure of Human Orexin-A:Regulator of Appetite and Wakefulness'''
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===Solution structure of Human Orexin-A:Regulator of Appetite and Wakefulness===
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==Overview==
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Orexin-A and orexin-B (hypocretin-1 and hypocretin-2, respectively) are important hypothalamic neuro-peptides, which are encoded by a single mRNA transcript and stimulate food intake as well as regulate wakefulness. Here we determined the solution structure of orexin-A by NMR spectroscopy and by simulated-annealing calculation. The structural features of orexin-A involve two alpha-helices, with the hydrophobic residues disposed to on one side of helix, and hydrophilic residues to the other. A hydrophilic turn induced by two disulfide bonds provides the key difference between orexin-A and -B. With previous mutagenic studies, the derived structure of orexin-A provides us with a structure-functional view for novel drug design.
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The line below this paragraph, {{ABSTRACT_PUBMED_15479620}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15479620 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15479620}}
==About this Structure==
==About this Structure==
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1R02 is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R02 OCA].
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1R02 is a [[Single protein]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R02 OCA].
==Reference==
==Reference==
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[[Category: Helix-loop-helix]]
[[Category: Helix-loop-helix]]
[[Category: Turn]]
[[Category: Turn]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:54:39 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 07:00:58 2008''

Revision as of 04:01, 28 July 2008

Image:1r02.png

Template:STRUCTURE 1r02

Solution structure of Human Orexin-A:Regulator of Appetite and Wakefulness

Template:ABSTRACT PUBMED 15479620

About this Structure

1R02 is a Single protein structure. Full experimental information is available from OCA.

Reference

Solution structure of human orexin-A: regulator of appetite and wakefulness., Kim HY, Hong E, Kim JI, Lee W, J Biochem Mol Biol. 2004 Sep 30;37(5):565-73. PMID:15479620

Page seeded by OCA on Mon Jul 28 07:00:58 2008

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