2gqq

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{{STRUCTURE_2gqq| PDB=2gqq | SCENE= }}
{{STRUCTURE_2gqq| PDB=2gqq | SCENE= }}
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'''Crystal Structure of E. coli Leucine-responsive regulatory protein (Lrp)'''
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===Crystal Structure of E. coli Leucine-responsive regulatory protein (Lrp)===
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==Overview==
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The structure of Escherichia coli leucine-responsive regulatory protein (Lrp) co-crystallized with a short duplex oligodeoxynucleotide reveals a novel quaternary assembly in which the protein octamer forms an open, linear array of four dimers. In contrast, structures of the Lrp homologs LrpA, LrpC and AsnC crystallized in the absence of DNA show that these proteins instead form highly symmetrical octamers in which the four dimers form a closed ring. Although the DNA is disordered within the Lrp crystal, comparative analyses suggest that the observed differences in quaternary state may arise from DNA interactions during crystallization. Interconversion of these conformations, possibly in response to DNA or leucine binding, provides an underlying mechanism to alter the relative spatial orientation of the DNA-binding domains. Breaking of the closed octamer symmetry may be a common essential step in the formation of active DNA complexes by all members of the Lrp/AsnC family of transcriptional regulatory proteins.
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The line below this paragraph, {{ABSTRACT_PUBMED_17223133}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 17223133 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17223133}}
==About this Structure==
==About this Structure==
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[[Category: Rios, S de los.]]
[[Category: Rios, S de los.]]
[[Category: Helix-turn-helix]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 05:24:52 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 07:06:46 2008''

Revision as of 04:06, 28 July 2008

Image:2gqq.png

Template:STRUCTURE 2gqq

Crystal Structure of E. coli Leucine-responsive regulatory protein (Lrp)

Template:ABSTRACT PUBMED 17223133

About this Structure

2GQQ is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Structure of the Escherichia coli leucine-responsive regulatory protein Lrp reveals a novel octameric assembly., de los Rios S, Perona JJ, J Mol Biol. 2007 Mar 9;366(5):1589-602. Epub 2006 Dec 19. PMID:17223133

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