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1myn

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[[Image:1myn.gif|left|200px]]
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{{STRUCTURE_1myn| PDB=1myn | SCENE= }}
{{STRUCTURE_1myn| PDB=1myn | SCENE= }}
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'''SOLUTION STRUCTURE OF DROSOMYCIN, THE FIRST INDUCIBLE ANTIFUNGAL PROTEIN FROM INSECTS, NMR, 15 STRUCTURES'''
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===SOLUTION STRUCTURE OF DROSOMYCIN, THE FIRST INDUCIBLE ANTIFUNGAL PROTEIN FROM INSECTS, NMR, 15 STRUCTURES===
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==Overview==
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Drosomycin is the first antifungal protein characterized recently among the broad family of inducible peptides and proteins produced by insects to respond to bacterial or septic injuries. It is a small protein of 44 amino acid residues extracted from Drosophila melanogaster that exhibits a potent activity against filamentous fungi. Its three-dimensional structure in aqueous solution was determined using 1H 2D NMR. This structure, involving an alpha-helix and a twisted three-stranded beta-sheet, is stabilized by three disulfide bridges. The corresponding Cysteine Stabilized alpha beta (CS alpha beta) motif, which was found in other defense proteins such as the antibacterial insect defensin A, short- and long-chain scorpion toxins, as well as in plant thionins and potent antifungal plant defensins, appears as remarkably persistent along evolution.
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(as it appears on PubMed at http://www.pubmed.gov), where 9300487 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9300487}}
==About this Structure==
==About this Structure==
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1MYN is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MYN OCA].
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1MYN is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MYN OCA].
==Reference==
==Reference==
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[[Category: Insect immunity]]
[[Category: Insect immunity]]
[[Category: Signal protein]]
[[Category: Signal protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 01:52:27 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 07:14:22 2008''

Revision as of 04:14, 28 July 2008

Image:1myn.png

Template:STRUCTURE 1myn

SOLUTION STRUCTURE OF DROSOMYCIN, THE FIRST INDUCIBLE ANTIFUNGAL PROTEIN FROM INSECTS, NMR, 15 STRUCTURES

Template:ABSTRACT PUBMED 9300487

About this Structure

1MYN is a Single protein structure of sequence from Drosophila melanogaster. Full experimental information is available from OCA.

Reference

Solution structure of drosomycin, the first inducible antifungal protein from insects., Landon C, Sodano P, Hetru C, Hoffmann J, Ptak M, Protein Sci. 1997 Sep;6(9):1878-84. PMID:9300487

Page seeded by OCA on Mon Jul 28 07:14:22 2008

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