1ny3

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[[Image:1ny3.gif|left|200px]]
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{{STRUCTURE_1ny3| PDB=1ny3 | SCENE= }}
{{STRUCTURE_1ny3| PDB=1ny3 | SCENE= }}
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'''Crystal structure of ADP bound to MAP KAP kinase 2'''
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===Crystal structure of ADP bound to MAP KAP kinase 2===
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==Overview==
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MAP KAP kinase 2 (MK2), a Ser/Thr kinase, plays a crucial role in the inflammatory process. We have determined the crystal structures of a catalytically active C-terminal deletion form of human MK2, residues 41-364, in complex with staurosporine at 2.7 A and with ADP at 3.2 A, revealing overall structural similarity with other Ser/Thr kinases. Kinetic analysis reveals that the K(m) for ATP is very similar for MK2 41-364 and p38-activated MK2 41-400. Conversely, the catalytic rate and binding for peptide substrate are dramatically reduced in MK2 41-364. However, phosphorylation of MK2 41-364 by p38 restores the V(max) and K(m) for peptide substrate to values comparable to those seen in p38-activated MK2 41-400, suggesting a mechanism for regulation of enzyme activity.
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(as it appears on PubMed at http://www.pubmed.gov), where 12791252 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12791252}}
==About this Structure==
==About this Structure==
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[[Category: Mk2]]
[[Category: Mk2]]
[[Category: Ser/thr kinase]]
[[Category: Ser/thr kinase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 03:07:14 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 07:16:14 2008''

Revision as of 04:16, 28 July 2008

Image:1ny3.png

Template:STRUCTURE 1ny3

Crystal structure of ADP bound to MAP KAP kinase 2

Template:ABSTRACT PUBMED 12791252

About this Structure

1NY3 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Catalytically active MAP KAP kinase 2 structures in complex with staurosporine and ADP reveal differences with the autoinhibited enzyme., Underwood KW, Parris KD, Federico E, Mosyak L, Czerwinski RM, Shane T, Taylor M, Svenson K, Liu Y, Hsiao CL, Wolfrom S, Maguire M, Malakian K, Telliez JB, Lin LL, Kriz RW, Seehra J, Somers WS, Stahl ML, Structure. 2003 Jun;11(6):627-36. PMID:12791252

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