This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
1gtk
From Proteopedia
OCA (Talk | contribs)
(New page: 200px<br /> <applet load="1gtk" size="450" color="white" frame="true" align="right" spinBox="true" caption="1gtk, resolution 1.66Å" /> '''TIME-RESOLVED AND S...)
Next diff →
Revision as of 18:20, 29 October 2007
|
TIME-RESOLVED AND STATIC-ENSEMBLE STRUCTURAL CHEMISTRY OF HYDROXYMETHYLBILANE SYNTHASE
Overview
The enzyme hydroxymethylbilane synthase (HMBS, EC 4.3.1.8), 313 amino acid, residues and MW 34 kDa, also known as porphobilinogen deaminase (PBGD), catalyses the stepwise polymerization of four molecules of porphobilinogen, (PBG) to the linear tetrapyrrole 1-hydroxymethylbilane. Several, crystallographic structures of HMBS have been previously determined, most, recently including by time-resolved Laue protein crystallography of the, Lys59Gln mutant form with reaction initiation undertaken by use of a flow, cell carrying the substrate PBG. In this paper we review these structures, and add new molecular graphics representations and analyses. Moreover we, present a new structure refined at 1.66 A resolution using diffraction, data recorded at cryo-temperature (100 K) in an attempt at ... [(full description)]
About this Structure
1GTK is a [Single protein] structure of sequence from [Escherichia coli] with DPM as [ligand]. Active as [[1]], with EC number [4.3.1.8]. Full crystallographic information is available from [OCA].
Reference
Time-resolved and static-ensemble structural chemistry of hydroxymethylbilane synthase., Helliwell JR, Nieh YP, Habash J, Faulder PF, Raftery J, Cianci M, Wulff M, Hadener A, Faraday Discuss. 2003;122:131-44; discussion 171-90. PMID:12555854
Page seeded by OCA on Mon Oct 29 20:25:09 2007
