This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1z92

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1z92.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1z92.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1z92| PDB=1z92 | SCENE= }}
{{STRUCTURE_1z92| PDB=1z92 | SCENE= }}
-
'''structure of interleukin-2 with its alpha receptor'''
+
===structure of interleukin-2 with its alpha receptor===
-
==Overview==
+
<!--
-
Interleukin-2 (IL-2) is an immunoregulatory cytokine that binds sequentially to the alpha (IL-2Ralpha), beta (IL-2Rbeta), and common gamma chain (gammac) receptor subunits. Here we present the 2.8 angstrom crystal structure of a complex between human IL-2 and IL-2Ralpha, which interact in a docking mode distinct from that of other cytokine receptor complexes. IL-2Ralpha is composed of strand-swapped "sushi-like" domains, unlike the classical cytokine receptor fold. As a result of this domain swap, IL-2Ralpha uses a composite surface to dock into a groove on IL-2 that also serves as a binding site for antagonist drugs. With this complex, we now have representative structures for each class of hematopoietic cytokine receptor-docking modules.
+
The line below this paragraph, {{ABSTRACT_PUBMED_15933202}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 15933202 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_15933202}}
==Disease==
==Disease==
Line 32: Line 36:
[[Category: Interleukin-2]]
[[Category: Interleukin-2]]
[[Category: Interleukin-2 alpha receptor]]
[[Category: Interleukin-2 alpha receptor]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 17:19:52 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 07:16:39 2008''

Revision as of 04:16, 28 July 2008

Image:1z92.png

Template:STRUCTURE 1z92

Contents

structure of interleukin-2 with its alpha receptor

Template:ABSTRACT PUBMED 15933202

Disease

Known disease associated with this structure: Severe combined immunodeficiency due to IL2 deficiency OMIM:[147680], Interleukin-2 receptor, alpha chain, deficiency of OMIM:[147730], Diabetes mellitus, insulin-dependent, susceptibility to, 10 OMIM:[147730]

About this Structure

1Z92 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The structure of interleukin-2 complexed with its alpha receptor., Rickert M, Wang X, Boulanger MJ, Goriatcheva N, Garcia KC, Science. 2005 Jun 3;308(5727):1477-80. PMID:15933202

Page seeded by OCA on Mon Jul 28 07:16:39 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1z92"
Personal tools