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1uds

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{{STRUCTURE_1uds| PDB=1uds | SCENE= }}
{{STRUCTURE_1uds| PDB=1uds | SCENE= }}
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'''Crystal structure of the tRNA processing enzyme RNase PH R126A mutant from Aquifex aeolicus'''
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===Crystal structure of the tRNA processing enzyme RNase PH R126A mutant from Aquifex aeolicus===
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==Overview==
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RNase PH is one of the exoribonucleases that catalyze the 3' end processing of tRNA in bacteria. RNase PH removes nucleotides following the CCA sequence of tRNA precursors by phosphorolysis and generates mature tRNAs with amino acid acceptor activity. In this study, we determined the crystal structure of Aquifex aeolicus RNase PH bound with a phosphate, a co-substrate, in the active site at 2.3-A resolution. RNase PH has the typical alpha/beta fold, which forms a hexameric ring structure as a trimer of dimers. This ring structure resembles that of the polynucleotide phosphorylase core domain homotrimer, another phosphorolytic exoribonuclease. Four amino acid residues, Arg-86, Gly-124, Thr-125, and Arg-126, of RNase PH are involved in the phosphate-binding site. Mutational analyses of these residues showed their importance in the phosphorolysis reaction. A docking model with the tRNA acceptor stem suggests how RNase PH accommodates substrate RNAs.
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(as it appears on PubMed at http://www.pubmed.gov), where 12746447 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12746447}}
==About this Structure==
==About this Structure==
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[[Category: Structural genomic]]
[[Category: Structural genomic]]
[[Category: Transferase]]
[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 11:04:45 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 07:16:47 2008''

Revision as of 04:16, 28 July 2008

Image:1uds.png

Template:STRUCTURE 1uds

Crystal structure of the tRNA processing enzyme RNase PH R126A mutant from Aquifex aeolicus

Template:ABSTRACT PUBMED 12746447

About this Structure

1UDS is a Single protein structure of sequence from Aquifex aeolicus. Full crystallographic information is available from OCA.

Reference

Crystal structure of the tRNA processing enzyme RNase PH from Aquifex aeolicus., Ishii R, Nureki O, Yokoyama S, J Biol Chem. 2003 Aug 22;278(34):32397-404. Epub 2003 May 12. PMID:12746447

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