1zbx

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[[Image:1zbx.gif|left|200px]]
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{{STRUCTURE_1zbx| PDB=1zbx | SCENE= }}
{{STRUCTURE_1zbx| PDB=1zbx | SCENE= }}
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'''Crystal structure of a Orc1p-Sir1p complex'''
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===Crystal structure of a Orc1p-Sir1p complex===
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==Overview==
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The interaction between silence information regulator 1 protein (Sir1p) and origin recognition complex 1 protein (Orc1p), the largest subunit of the origin recognition complex, plays an important role in the establishment of transcriptional silencing at the cryptic mating-type gene loci in Saccharomyces cerevisiae. Sir1p binds the N-terminal region of Orc1p encompassing a Bromo-adjacent homology (BAH) domain found in various chromatin-associated proteins. To understand the molecular mechanism of Sir protein recruitment, we have determined a 2.5-A cocrystal structure of the N-terminal domain of Orc1p in complex with the Orc1p-interacting domain of Sir1p. The structure reveals that Sir1p Orc1p-interacting domain has a bilobal structure: an alpha/beta N-terminal lobe and a C-terminal lobe resembling the Tudor domain royal family fold. The N-terminal lobe of Sir1p binds in a shallow groove between a helical subdomain and the BAH domain of Orc1p. The structure provides a mechanistic understanding of Orc1p-Sir1p interaction specificity, as well as insights into protein-protein interactions involving BAH domains in general.
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The line below this paragraph, {{ABSTRACT_PUBMED_15937111}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15937111 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15937111}}
==About this Structure==
==About this Structure==
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[[Category: Silencing]]
[[Category: Silencing]]
[[Category: Silent information regulator]]
[[Category: Silent information regulator]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 17:26:20 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 07:21:35 2008''

Revision as of 04:21, 28 July 2008

Image:1zbx.png

Template:STRUCTURE 1zbx

Crystal structure of a Orc1p-Sir1p complex

Template:ABSTRACT PUBMED 15937111

About this Structure

1ZBX is a Protein complex structure of sequences from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Structural basis for origin recognition complex 1 protein-silence information regulator 1 protein interaction in epigenetic silencing., Hsu HC, Stillman B, Xu RM, Proc Natl Acad Sci U S A. 2005 Jun 14;102(24):8519-24. Epub 2005 Jun 3. PMID:15937111

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