1lvn
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(New page: 200px<br /><applet load="1lvn" size="450" color="white" frame="true" align="right" spinBox="true" caption="1lvn, resolution 2.40Å" /> '''CRYSTAL STRUCTURE OF...)
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Revision as of 18:48, 20 November 2007
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CRYSTAL STRUCTURE OF E. COLI AMINE OXIDASE COMPLEXED WITH TRANYLCYPROMINE
Overview
The X-ray crystal structure of the copper-containing quinoprotein amine, oxidase from E. coli has been determined in complex with the, antidepressant drug tranylcypromine to 2.4 A resolution. The drug is a, racemic mix of two enantiomers, but only one is seen bound to the enzyme., The other enantiomer is not acting as a substrate for the enzyme as no, catalytic activity was detected when the enzyme was initially exposed to, the drug. The inhibition of human copper amine oxidases could be a source, of side-effects in its use as an antidepressant to inhibit the, flavin-containing monoamine oxidases in the brain.
About this Structure
1LVN is a Single protein structure of sequence from Escherichia coli with CU and CA as ligands. Active as Amine oxidase (copper-containing), with EC number 1.4.3.6 Full crystallographic information is available from OCA.
Reference
Medical implications from the crystal structure of a copper-containing amine oxidase complexed with the antidepressant drug tranylcypromine., Wilmot CM, Saysell CG, Blessington A, Conn DA, Kurtis CR, McPherson MJ, Knowles PF, Phillips SE, FEBS Lett. 2004 Oct 22;576(3):301-5. PMID:15498552
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