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2ayp

From Proteopedia

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[[Image:2ayp.gif|left|200px]]
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[[Image:2ayp.png|left|200px]]
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{{STRUCTURE_2ayp| PDB=2ayp | SCENE= }}
{{STRUCTURE_2ayp| PDB=2ayp | SCENE= }}
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'''Crystal Structure of CHK1 with an Indol Inhibitor'''
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===Crystal Structure of CHK1 with an Indol Inhibitor===
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==Overview==
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Chk1 inhibitors have emerged as a novel class of neoplastic agents for abrogating the G2 DNA damage checkpoint arrest. Analogs of the Chk1 inhibitor, 3-ethylidene-1,3-dihydro-indol-2-one, were synthesized and tested in vitro for their inhibitory activities. The most promising compound identified from this series is analog 28, which possesses potent enzymatic and cellular activities.
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(as it appears on PubMed at http://www.pubmed.gov), where 16242328 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16242328}}
==About this Structure==
==About this Structure==
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[[Category: Zhang, H.]]
[[Category: Zhang, H.]]
[[Category: Protein-inhibitor complex]]
[[Category: Protein-inhibitor complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 19:38:07 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 07:26:26 2008''

Revision as of 04:26, 28 July 2008

Image:2ayp.png

Template:STRUCTURE 2ayp

Crystal Structure of CHK1 with an Indol Inhibitor

Template:ABSTRACT PUBMED 16242328

About this Structure

2AYP is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Synthesis and biological evaluation of 3-ethylidene-1,3-dihydro-indol-2-ones as novel checkpoint 1 inhibitors., Lin NH, Xia P, Kovar P, Park C, Chen Z, Zhang H, Rosenberg SH, Sham HL, Bioorg Med Chem Lett. 2006 Jan 15;16(2):421-6. Epub 2005 Oct 18. PMID:16242328

Page seeded by OCA on Mon Jul 28 07:26:26 2008

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