2h6j

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[[Image:2h6j.gif|left|200px]]
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{{STRUCTURE_2h6j| PDB=2h6j | SCENE= }}
{{STRUCTURE_2h6j| PDB=2h6j | SCENE= }}
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'''Crystal Structure of the Beta F145A Rhodococcus Proteasome (CASP Target)'''
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===Crystal Structure of the Beta F145A Rhodococcus Proteasome (CASP Target)===
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==Overview==
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The processing of propeptides and the maturation of 20S proteasomes require the association of beta rings from two half proteasomes. We propose an assembly-dependent activation model in which interactions between helix (H3 and H4) residues of the opposing half proteasomes are prerequisite for appropriate positioning of the S2-S3 loop; such positioning enables correct coordination of the active-site residue needed for propeptide cleavage. Mutations of H3 or H4 residues that participate in the association of two half proteasomes inhibit activation and prevent, in nearly all cases, the formation of full proteasomes. In contrast, mutations affecting interactions with residues of the S2-S3 loop allow the assembly of full, but activity impacted, proteasomes. The crystal structure of the inactive H3 mutant, Phe145Ala, shows that the S2-S3 loop is displaced from the position observed in wild-type proteasomes. These data support the proposed assembly-dependent activation model in which the S2-S3 loop acts as an activation switch.
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The line below this paragraph, {{ABSTRACT_PUBMED_16843899}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 16843899 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16843899}}
==About this Structure==
==About this Structure==
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[[Category: Assembly-dependent activation]]
[[Category: Assembly-dependent activation]]
[[Category: Half proteasome]]
[[Category: Half proteasome]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 05:55:39 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 07:30:24 2008''

Revision as of 04:30, 28 July 2008

Image:2h6j.png

Template:STRUCTURE 2h6j

Crystal Structure of the Beta F145A Rhodococcus Proteasome (CASP Target)

Template:ABSTRACT PUBMED 16843899

About this Structure

2H6J is a Protein complex structure of sequences from Rhodococcus erythropolis. Full crystallographic information is available from OCA.

Reference

Proteasome assembly triggers a switch required for active-site maturation., Witt S, Kwon YD, Sharon M, Felderer K, Beuttler M, Robinson CV, Baumeister W, Jap BK, Structure. 2006 Jul;14(7):1179-88. PMID:16843899

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