2poi

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{{STRUCTURE_2poi| PDB=2poi | SCENE= }}
{{STRUCTURE_2poi| PDB=2poi | SCENE= }}
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'''Crystal structure of XIAP BIR1 domain (I222 form)'''
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===Crystal structure of XIAP BIR1 domain (I222 form)===
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==Overview==
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In addition to caspase inhibition, X-linked inhibitor of apoptosis (XIAP) induces NF-kappaB and MAP kinase activation during TGF-b and BMP receptor signaling and upon overexpression. Here we show that the BIR1 domain of XIAP, which has no previously ascribed function, directly interacts with TAB1 to induce NF-kappaB activation. TAB1 is an upstream adaptor for the activation of the kinase TAK1, which in turn couples to the NF-kappaB pathway. We report the crystal structures of BIR1, TAB1, and the BIR1/TAB1 complex. The BIR1/TAB1 structure reveals a striking butterfly-shaped dimer and the detailed interaction between BIR1 and TAB1. Structure-based mutagenesis and knockdown of TAB1 show unambiguously that the BIR1/TAB1 interaction is crucial for XIAP-induced TAK1 and NF-kappaB activation. We show that although not interacting with BIR1, Smac, the antagonist for caspase inhibition by XIAP, also inhibits the XIAP/TAB1 interaction. Disruption of BIR1 dimerization abolishes XIAP-mediated NF-kappaB activation, implicating a proximity-induced mechanism for TAK1 activation.
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{{ABSTRACT_PUBMED_17560374}}
==About this Structure==
==About this Structure==
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[[Category: Lin, S.]]
[[Category: Lin, S.]]
[[Category: Zinc finger]]
[[Category: Zinc finger]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 13:32:25 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 07:36:29 2008''

Revision as of 04:36, 28 July 2008

Image:2poi.png

Template:STRUCTURE 2poi

Crystal structure of XIAP BIR1 domain (I222 form)

Template:ABSTRACT PUBMED 17560374

About this Structure

2POI is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

XIAP induces NF-kappaB activation via the BIR1/TAB1 interaction and BIR1 dimerization., Lu M, Lin SC, Huang Y, Kang YJ, Rich R, Lo YC, Myszka D, Han J, Wu H, Mol Cell. 2007 Jun 8;26(5):689-702. PMID:17560374

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