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2c4u

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[[Image:2c4u.gif|left|200px]]
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{{Seed}}
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[[Image:2c4u.png|left|200px]]
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{{STRUCTURE_2c4u| PDB=2c4u | SCENE= }}
{{STRUCTURE_2c4u| PDB=2c4u | SCENE= }}
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'''CRYSTAL STRUCTURE OF THE APO FORM OF THE 5'-FLUORO-5'-DEOXYADENOSINE SYNTHASE ENZYME FROM STREPTOMYCES CATTLEYA'''
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===CRYSTAL STRUCTURE OF THE APO FORM OF THE 5'-FLUORO-5'-DEOXYADENOSINE SYNTHASE ENZYME FROM STREPTOMYCES CATTLEYA===
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==Overview==
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The fluorinase enzyme from Streptomyces cattleya displays an unusual ability in biocatalysis in that it forms a C-F bond. We now report that the enzyme will accept 2'-deoxyadenosine in place of adenosine substrates, and structural evidence reveals a reorganisation in hydrogen bonding to accommodate this substrate series. It emerges from this study that the enzyme does not require a planar ribose conformation of the substrate to catalyse C-F bond formation.
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(as it appears on PubMed at http://www.pubmed.gov), where 16604208 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16604208}}
==About this Structure==
==About this Structure==
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[[Category: Sam]]
[[Category: Sam]]
[[Category: Transferase]]
[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 21:15:13 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 07:40:28 2008''

Revision as of 04:40, 28 July 2008

Image:2c4u.png

Template:STRUCTURE 2c4u

CRYSTAL STRUCTURE OF THE APO FORM OF THE 5'-FLUORO-5'-DEOXYADENOSINE SYNTHASE ENZYME FROM STREPTOMYCES CATTLEYA

Template:ABSTRACT PUBMED 16604208

About this Structure

2C4U is a Single protein structure of sequence from Streptomyces cattleya. Full crystallographic information is available from OCA.

Reference

Substrate specificity in enzymatic fluorination. The fluorinase from Streptomyces cattleya accepts 2'-deoxyadenosine substrates., Cobb SL, Deng H, McEwan AR, Naismith JH, O'Hagan D, Robinson DA, Org Biomol Chem. 2006 Apr 21;4(8):1458-60. Epub 2006 Mar 8. PMID:16604208

Page seeded by OCA on Mon Jul 28 07:40:28 2008

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