1qg3

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{{STRUCTURE_1qg3| PDB=1qg3 | SCENE= }}
{{STRUCTURE_1qg3| PDB=1qg3 | SCENE= }}
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'''CRYSTAL STRUCTURE OF A TANDEM PAIR OF FIBRONECTIN TYPE III DOMAINS FROM THE CYTOPLASMIC TAIL OF INTEGRIN ALPHA6 BETA4'''
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===CRYSTAL STRUCTURE OF A TANDEM PAIR OF FIBRONECTIN TYPE III DOMAINS FROM THE CYTOPLASMIC TAIL OF INTEGRIN ALPHA6 BETA4===
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==Overview==
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The integrin alpha6beta4 is an essential component of hemidesmosomes but it also plays a dynamic role in invasive carcinoma cells. The cytoplasmic tail of the beta4 subunit is uniquely large among integrins and includes two pairs of fibronectin type III domains separated by a connecting segment. Here we describe the crystal structure of the first tandem domain pair, a module that is critical for alpha6beta4 function. The structure reveals a novel interdomain interface and candidate protein-binding sites, including a large acidic cleft formed from the surfaces of both domains and a prominent loop that is reminiscent of the RGD integrin-binding loop of fibronectin. This is the first crystal structure of either a hemidesmosome component or an integrin cytoplasmic domain, and it will enable the intracellular functions of alpha6beta4 to be dissected at the atomic level.
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{{ABSTRACT_PUBMED_10428948}}
==Disease==
==Disease==
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[[Category: Hemidesmosome]]
[[Category: Hemidesmosome]]
[[Category: Integrin]]
[[Category: Integrin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:13:41 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 07:45:00 2008''

Revision as of 04:45, 28 July 2008

Image:1qg3.png

Template:STRUCTURE 1qg3

Contents

CRYSTAL STRUCTURE OF A TANDEM PAIR OF FIBRONECTIN TYPE III DOMAINS FROM THE CYTOPLASMIC TAIL OF INTEGRIN ALPHA6 BETA4

Template:ABSTRACT PUBMED 10428948

Disease

Known disease associated with this structure: Epidermolysis bullosa of hands and feet OMIM:[147557], Epidermolysis bullosa, generalized atrophic benign OMIM:[147557], Epidermolysis bullosa, junctional, with pyloric atresia OMIM:[147557]

About this Structure

1QG3 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of a tandem pair of fibronectin type III domains from the cytoplasmic tail of integrin alpha6beta4., de Pereda JM, Wiche G, Liddington RC, EMBO J. 1999 Aug 2;18(15):4087-95. PMID:10428948

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