1u8g

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{{STRUCTURE_1u8g| PDB=1u8g | SCENE= }}
{{STRUCTURE_1u8g| PDB=1u8g | SCENE= }}
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'''Crystal structure of a HIV-1 Protease in complex with peptidomimetic inhibitor KI2-PHE-GLU-GLU-NH2'''
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===Crystal structure of a HIV-1 Protease in complex with peptidomimetic inhibitor KI2-PHE-GLU-GLU-NH2===
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==Overview==
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Depending on the excess of ligand used for complex formation, the HIV-1 protease complexed with a novel phenylnorstatine inhibitor forms crystals of either hexagonal (P6(1)) or orthorhombic (P2(1)2(1)2(1)) symmetry. The orthorhombic form shows an unusual complexity of crystal packing: in addition to one inhibitor molecule that is bound to the enzyme active site, the second inhibitor molecule is bound as an outer ligand at the protein interface. Binding of the outer ligand apparently increases the crystal-quality parameters so that the diffraction data allow solution of the structure of the complex at 1.03 A, the best resolution reported to date. The outer ligand interacts with all four surrounding HIV-1 protease molecules and has a bent conformation owing to its accommodation in the intermolecular space. The parameters of the solved structures of the orthorhombic and hexagonal forms are compared.
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{{ABSTRACT_PUBMED_15502300}}
==About this Structure==
==About this Structure==
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[[Category: Hydrolase/hydrolase inhibitor]]
[[Category: Hydrolase/hydrolase inhibitor]]
[[Category: Inhibitor design]]
[[Category: Inhibitor design]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 10:53:39 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 07:45:43 2008''

Revision as of 04:45, 28 July 2008

Image:1u8g.png

Template:STRUCTURE 1u8g

Crystal structure of a HIV-1 Protease in complex with peptidomimetic inhibitor KI2-PHE-GLU-GLU-NH2

Template:ABSTRACT PUBMED 15502300

About this Structure

1U8G is a Single protein structure of sequence from Human immunodeficiency virus 1. Full crystallographic information is available from OCA.

Reference

Inhibitor binding at the protein interface in crystals of a HIV-1 protease complex., Brynda J, Rezacova P, Fabry M, Horejsi M, Stouracova R, Soucek M, Hradilek M, Konvalinka J, Sedlacek J, Acta Crystallogr D Biol Crystallogr. 2004 Nov;60(Pt 11):1943-8. Epub 2004, Oct 20. PMID:15502300

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