3d0b

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:3d0b.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:3d0b.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_3d0b| PDB=3d0b | SCENE= }}
{{STRUCTURE_3d0b| PDB=3d0b | SCENE= }}
-
'''Crystal Structure of Benzamide Tetrahydro-4H-carbazol-4-one bound to Hsp90'''
+
===Crystal Structure of Benzamide Tetrahydro-4H-carbazol-4-one bound to Hsp90===
-
==Overview==
+
<!--
-
Hsp90 maintains the conformational stability of multiple proteins implicated in oncogenesis and has emerged as a target for chemotherapy. We report here the discovery of a novel small molecule scaffold that inhibits Hsp90. X-ray data show that the scaffold binds competitively at the ATP site on Hsp90. Cellular proliferation and client assays demonstrate that members of the series are able to inhibit Hsp90 at nanomolar concentrations.
+
The line below this paragraph, {{ABSTRACT_PUBMED_18511277}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 18511277 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_18511277}}
==About this Structure==
==About this Structure==
Line 35: Line 39:
[[Category: Phosphoprotein]]
[[Category: Phosphoprotein]]
[[Category: Stress response]]
[[Category: Stress response]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 18 12:12:17 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 07:47:40 2008''

Revision as of 04:47, 28 July 2008

Image:3d0b.png

Template:STRUCTURE 3d0b

Crystal Structure of Benzamide Tetrahydro-4H-carbazol-4-one bound to Hsp90

Template:ABSTRACT PUBMED 18511277

About this Structure

3D0B is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Discovery of benzamide tetrahydro-4H-carbazol-4-ones as novel small molecule inhibitors of Hsp90., Barta TE, Veal JM, Rice JW, Partridge JM, Fadden RP, Ma W, Jenks M, Geng L, Hanson GJ, Huang KH, Barabasz AF, Foley BE, Otto J, Hall SE, Bioorg Med Chem Lett. 2008 Jun 15;18(12):3517-21. Epub 2008 May 9. PMID:18511277

Page seeded by OCA on Mon Jul 28 07:47:40 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3d0b"
Personal tools