2pxj

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:2pxj.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:2pxj.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2pxj| PDB=2pxj | SCENE= }}
{{STRUCTURE_2pxj| PDB=2pxj | SCENE= }}
-
'''The complex structure of JMJD2A and monomethylated H3K36 peptide'''
+
===The complex structure of JMJD2A and monomethylated H3K36 peptide===
-
==Overview==
+
<!--
-
The Jumonji C domain is a catalytic motif that mediates histone lysine demethylation. The Jumonji C-containing oxygenase JMJD2A specifically demethylates tri- and dimethylated lysine-9 and lysine-36 of histone 3 (H3K9/36 me3/2). Here we present structures of the JMJD2A catalytic core complexed with methylated H3K36 peptide substrates in the presence of Fe(II) and N-oxalylglycine. We found that the interaction between JMJD2A and peptides largely involves the main chains of the enzyme and the peptide. The peptide-binding specificity is primarily determined by the primary structure of the peptide, which explains the specificity of JMJD2A for methylated H3K9 and H3K36 instead of other methylated residues such as H3K27. The specificity for a particular methyl group, however, is affected by multiple factors, such as space and the electrostatic environment in the catalytic center of the enzyme. These results provide insights into the mechanisms and specificity of histone demethylation.
+
The line below this paragraph, {{ABSTRACT_PUBMED_17567753}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 17567753 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_17567753}}
==About this Structure==
==About this Structure==
Line 32: Line 36:
[[Category: Jmjc]]
[[Category: Jmjc]]
[[Category: Jmjd2a]]
[[Category: Jmjd2a]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 13:58:42 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 07:51:28 2008''

Revision as of 04:51, 28 July 2008

Image:2pxj.png

Template:STRUCTURE 2pxj

The complex structure of JMJD2A and monomethylated H3K36 peptide

Template:ABSTRACT PUBMED 17567753

About this Structure

2PXJ is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural basis of the recognition of a methylated histone tail by JMJD2A., Chen Z, Zang J, Kappler J, Hong X, Crawford F, Wang Q, Lan F, Jiang C, Whetstine J, Dai S, Hansen K, Shi Y, Zhang G, Proc Natl Acad Sci U S A. 2007 Jun 26;104(26):10818-23. Epub 2007 Jun 13. PMID:17567753

Page seeded by OCA on Mon Jul 28 07:51:28 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2pxj"
Personal tools