2d1l

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{{STRUCTURE_2d1l| PDB=2d1l | SCENE= }}
{{STRUCTURE_2d1l| PDB=2d1l | SCENE= }}
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'''Structure of F-actin binding domain IMD of MIM (Missing In Metastasis)'''
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===Structure of F-actin binding domain IMD of MIM (Missing In Metastasis)===
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==Overview==
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The adaptor protein missing-in-metastasis (MIM) contains independent F- and G-actin binding domains, consisting, respectively, of an N-terminal 250 aa IRSp53/MIM homology domain (IMD) and a C-terminal WASP-homology domain 2 (WH2). We determined the crystal structures of MIM's IMD and that of its WH2 bound to actin. The IMD forms a dimer, with each subunit folded as an antiparallel three-helix bundle. This fold is related to that of the BAR domain. Like the BAR domain, the IMD has been implicated in membrane binding. Yet, comparison of the structures reveals that the membrane binding surfaces of the two domains have opposite curvatures, which may determine the type of curvature of the interacting membrane. The WH2 of MIM is longer than the prototypical WH2, interacting with all four subdomains of actin. We characterize a similar WH2 at the C terminus of IRSp53 and propose that in these two proteins WH2 performs a scaffolding function.
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(as it appears on PubMed at http://www.pubmed.gov), where 17292833 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17292833}}
==About this Structure==
==About this Structure==
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[[Category: Imd]]
[[Category: Imd]]
[[Category: Irsp53]]
[[Category: Irsp53]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 23:31:29 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 07:56:27 2008''

Revision as of 04:56, 28 July 2008

Image:2d1l.png

Template:STRUCTURE 2d1l

Structure of F-actin binding domain IMD of MIM (Missing In Metastasis)

Template:ABSTRACT PUBMED 17292833

About this Structure

2D1L is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

Structural basis for the actin-binding function of missing-in-metastasis., Lee SH, Kerff F, Chereau D, Ferron F, Klug A, Dominguez R, Structure. 2007 Feb;15(2):145-55. PMID:17292833

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