This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2oo4

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:2oo4.gif|left|200px]]
+
{{Seed}}
 +
[[Image:2oo4.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2oo4| PDB=2oo4 | SCENE= }}
{{STRUCTURE_2oo4| PDB=2oo4 | SCENE= }}
-
'''Structure of LNR-HD (Negative Regulatory Region) from human Notch 2'''
+
===Structure of LNR-HD (Negative Regulatory Region) from human Notch 2===
-
==Overview==
+
<!--
-
Notch receptors transmit signals between adjacent cells. Signaling is initiated when ligand binding induces metalloprotease cleavage of Notch within an extracellular negative regulatory region (NRR). We present here the X-ray structure of the human NOTCH2 NRR, which adopts an autoinhibited conformation. Extensive interdomain interactions within the NRR bury the metalloprotease site, showing that a substantial conformational movement is necessary to expose this site during activation by ligand. Leukemia-associated mutations in NOTCH1 probably release autoinhibition by destabilizing the conserved hydrophobic core of the NRR.
+
The line below this paragraph, {{ABSTRACT_PUBMED_17401372}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 17401372 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_17401372}}
==Disease==
==Disease==
Line 37: Line 41:
[[Category: Lnr]]
[[Category: Lnr]]
[[Category: Sea domain]]
[[Category: Sea domain]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 11:18:20 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 07:57:13 2008''

Revision as of 04:57, 28 July 2008

Image:2oo4.png

Template:STRUCTURE 2oo4

Contents

Structure of LNR-HD (Negative Regulatory Region) from human Notch 2

Template:ABSTRACT PUBMED 17401372

Disease

Known disease associated with this structure: Alagille syndrome 2 OMIM:[600275]

About this Structure

2OO4 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural basis for autoinhibition of Notch., Gordon WR, Vardar-Ulu D, Histen G, Sanchez-Irizarry C, Aster JC, Blacklow SC, Nat Struct Mol Biol. 2007 Apr;14(4):295-300. Epub 2007 Apr 1. PMID:17401372

Page seeded by OCA on Mon Jul 28 07:57:13 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2oo4"
Personal tools