2fno

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{{STRUCTURE_2fno| PDB=2fno | SCENE= }}
{{STRUCTURE_2fno| PDB=2fno | SCENE= }}
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'''Crystal structure of Putative glutathione S-transferase (15162326) from AGROBACTERIUM TUMEFACIENS at 2.00 A resolution'''
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===Crystal structure of Putative glutathione S-transferase (15162326) from AGROBACTERIUM TUMEFACIENS at 2.00 A resolution===
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==Overview==
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Glutathione S-transferases (GSTs) comprise a diverse superfamily of enzymes found in organisms from all kingdoms of life. GSTs are involved in diverse processes, notably small-molecule biosynthesis or detoxification, and are frequently also used in protein engineering studies or as biotechnology tools. Here, we report the high-resolution X-ray structure of Atu5508 from the pathogenic soil bacterium Agrobacterium tumefaciens (atGST1). Through use of comparative sequence and structural analysis of the GST superfamily, we identified local sequence and structural signatures, which allowed us to distinguish between different GST classes. This approach enables GST classification based on structure, without requiring additional biochemical or immunological data. Consequently, analysis of the atGST1 crystal structure suggests a new GST class, distinct from previously characterized GSTs, which would make it an attractive target for further biochemical studies.
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(as it appears on PubMed at http://www.pubmed.gov), where 16988933 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16988933}}
==About this Structure==
==About this Structure==
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[[Category: Putative glutathione s-transferase]]
[[Category: Putative glutathione s-transferase]]
[[Category: Structural genomic]]
[[Category: Structural genomic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 08:00:31 2008''

Revision as of 05:00, 28 July 2008

Image:2fno.png

Template:STRUCTURE 2fno

Crystal structure of Putative glutathione S-transferase (15162326) from AGROBACTERIUM TUMEFACIENS at 2.00 A resolution

Template:ABSTRACT PUBMED 16988933

About this Structure

2FNO is a Single protein structure of sequence from Agrobacterium tumefaciens str. c58. This structure supersedes the now removed PDB entry 1zgm. Full crystallographic information is available from OCA.

Reference

Comparative structural analysis of a novel glutathioneS-transferase (ATU5508) from Agrobacterium tumefaciens at 2.0 A resolution., Kosloff M, Han GW, Krishna SS, Schwarzenbacher R, Fasnacht M, Elsliger MA, Abdubek P, Agarwalla S, Ambing E, Astakhova T, Axelrod HL, Canaves JM, Carlton D, Chiu HJ, Clayton T, DiDonato M, Duan L, Feuerhelm J, Grittini C, Grzechnik SK, Hale J, Hampton E, Haugen J, Jaroszewski L, Jin KK, Johnson H, Klock HE, Knuth MW, Koesema E, Kreusch A, Kuhn P, Levin I, McMullan D, Miller MD, Morse AT, Moy K, Nigoghossian E, Okach L, Oommachen S, Page R, Paulsen J, Quijano K, Reyes R, Rife CL, Sims E, Spraggon G, Sridhar V, Stevens RC, van den Bedem H, Velasquez J, White A, Wolf G, Xu Q, Hodgson KO, Wooley J, Deacon AM, Godzik A, Lesley SA, Wilson IA, Proteins. 2006 Nov 15;65(3):527-37. PMID:16988933

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