1snk

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{{STRUCTURE_1snk| PDB=1snk | SCENE= }}
{{STRUCTURE_1snk| PDB=1snk | SCENE= }}
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'''Cathepsin K complexed with carbamate derivatized norleucine aldehyde'''
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===Cathepsin K complexed with carbamate derivatized norleucine aldehyde===
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==Overview==
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The synthesis and biological activity of a series of aldehyde inhibitors of cathepsin K are reported. Exploration of the properties of the S2 and S3 subsites with a series of carbamate derivatized norleucine aldehydes substituted at the P2 and P3 positions afforded analogs with cathepsin K IC50s between 600 nM and 130 pM.
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(as it appears on PubMed at http://www.pubmed.gov), where 15177446 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15177446}}
==About this Structure==
==About this Structure==
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[[Category: Wright, L L.]]
[[Category: Wright, L L.]]
[[Category: Catk]]
[[Category: Catk]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 08:55:25 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 08:05:28 2008''

Revision as of 05:05, 28 July 2008

Template:STRUCTURE 1snk

Cathepsin K complexed with carbamate derivatized norleucine aldehyde

Template:ABSTRACT PUBMED 15177446

About this Structure

1SNK is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Exploration of the P2-P3 SAR of aldehyde cathepsin K inhibitors., Boros EE, Deaton DN, Hassell AM, McFadyen RB, Miller AB, Miller LR, Paulick MG, Shewchuk LM, Thompson JB, Willard DH Jr, Wright LL, Bioorg Med Chem Lett. 2004 Jul 5;14(13):3425-9. PMID:15177446

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