This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.


Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1snk

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1snk.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1snk.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1snk| PDB=1snk | SCENE= }}
{{STRUCTURE_1snk| PDB=1snk | SCENE= }}
-
'''Cathepsin K complexed with carbamate derivatized norleucine aldehyde'''
+
===Cathepsin K complexed with carbamate derivatized norleucine aldehyde===
-
==Overview==
+
<!--
-
The synthesis and biological activity of a series of aldehyde inhibitors of cathepsin K are reported. Exploration of the properties of the S2 and S3 subsites with a series of carbamate derivatized norleucine aldehydes substituted at the P2 and P3 positions afforded analogs with cathepsin K IC50s between 600 nM and 130 pM.
+
The line below this paragraph, {{ABSTRACT_PUBMED_15177446}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 15177446 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_15177446}}
==About this Structure==
==About this Structure==
Line 34: Line 38:
[[Category: Wright, L L.]]
[[Category: Wright, L L.]]
[[Category: Catk]]
[[Category: Catk]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 08:55:25 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 08:05:28 2008''

Revision as of 05:05, 28 July 2008

Template:STRUCTURE 1snk

Cathepsin K complexed with carbamate derivatized norleucine aldehyde

Template:ABSTRACT PUBMED 15177446

About this Structure

1SNK is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Exploration of the P2-P3 SAR of aldehyde cathepsin K inhibitors., Boros EE, Deaton DN, Hassell AM, McFadyen RB, Miller AB, Miller LR, Paulick MG, Shewchuk LM, Thompson JB, Willard DH Jr, Wright LL, Bioorg Med Chem Lett. 2004 Jul 5;14(13):3425-9. PMID:15177446

Page seeded by OCA on Mon Jul 28 08:05:28 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Personal tools