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2owy

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[[Image:2owy.jpg|left|200px]]
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{{STRUCTURE_2owy| PDB=2owy | SCENE= }}
{{STRUCTURE_2owy| PDB=2owy | SCENE= }}
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'''The recombination-associated protein RdgC adopts a novel toroidal architecture for DNA binding'''
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===The recombination-associated protein RdgC adopts a novel toroidal architecture for DNA binding===
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==Overview==
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RecA plays a central role in the nonmutagenic repair of stalled replication forks in bacteria. RdgC, a recombination-associated DNA-binding protein, is a potential negative regulator of RecA function. Here, we have determined the crystal structure of RdgC from Pseudomonas aeruginosa. The J-shaped monomer has a unique fold and can be divided into three structural domains: tip domain, center domain and base domain. Two such monomers dimerize to form a ring-shaped molecule of approximate 2-fold symmetry. Of the two inter-subunit interfaces within the dimer, one interface ('interface A') between tip/center domains is more nonpolar than the other ('interface B') between base domains. The structure allows us to propose that the RdgC dimer binds dsDNA through the central hole of approximately 30 A diameter. The proposed model is supported by our DNA-binding assays coupled with mutagenesis, which indicate that the conserved positively charged residues on the protein surface around the central hole play important roles in DNA binding. The novel ring-shaped architecture of the RdgC dimer has significant implications for its role in homologous recombination.
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The line below this paragraph, {{ABSTRACT_PUBMED_17426134}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 17426134 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17426134}}
==About this Structure==
==About this Structure==
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[[Category: Reca]]
[[Category: Reca]]
[[Category: Ring-shaped dna binding protein]]
[[Category: Ring-shaped dna binding protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 11:50:22 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 08:07:35 2008''

Revision as of 05:07, 28 July 2008

Image:2owy.png

Template:STRUCTURE 2owy

The recombination-associated protein RdgC adopts a novel toroidal architecture for DNA binding

Template:ABSTRACT PUBMED 17426134

About this Structure

2OWY is a Single protein structure of sequence from Pseudomonas aeruginosa. Full crystallographic information is available from OCA.

Reference

The recombination-associated protein RdgC adopts a novel toroidal architecture for DNA binding., Ha JY, Kim HK, Kim do J, Kim KH, Oh SJ, Lee HH, Yoon HJ, Song HK, Suh SW, Nucleic Acids Res. 2007;35(8):2671-81. Epub 2007 Apr 10. PMID:17426134

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