1jy4

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1jy4.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:1jy4.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1jy4| PDB=1jy4 | SCENE= }}
{{STRUCTURE_1jy4| PDB=1jy4 | SCENE= }}
-
'''B4DIMER: A DE NOVO DESIGNED EIGHT-STRANDED BETA-SHEET ASSEMBLED USING A DISULFIDE BOND'''
+
===B4DIMER: A DE NOVO DESIGNED EIGHT-STRANDED BETA-SHEET ASSEMBLED USING A DISULFIDE BOND===
-
==Overview==
+
<!--
-
The design and characterization of an open eight-stranded beta-sheet in a synthetic, 2-fold symmetric 70-residue peptide is described. The design strategy involves the generation of a 35-residue four-stranded beta-sheet peptide in which successive hairpins are nucleated by appropriately positioned (D)Pro-Xxx sequences. Oxidative dimerization using a single Cys residue positioned at the center of the C-terminal strand results in a disulfide-bridged eight-stranded structure. Nuclear Overhauser effects firmly establish an eight-stranded beta-sheet in methanol. In water, the outer strands are frayed, but a well-defined four-stranded beta-sheet stabilized by a disulfide bridge and a hydrophobic cluster is determined from NMR data. Comparison of the precursor peptide with the disulfide-bridged dimer reveals considerable enhancement of beta-sheet content in the latter, suggesting that the disulfide cross-link is an effective strategy for the stabilization of beta-sheets.
+
The line below this paragraph, {{ABSTRACT_PUBMED_11982362}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 11982362 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_11982362}}
==About this Structure==
==About this Structure==
-
Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JY4 OCA].
+
Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JY4 OCA].
==Reference==
==Reference==
Line 26: Line 30:
[[Category: Disulfide bond]]
[[Category: Disulfide bond]]
[[Category: Eight-stranded beta-sheet]]
[[Category: Eight-stranded beta-sheet]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:03:54 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 08:07:36 2008''

Revision as of 05:07, 28 July 2008

Image:1jy4.png

Template:STRUCTURE 1jy4

B4DIMER: A DE NOVO DESIGNED EIGHT-STRANDED BETA-SHEET ASSEMBLED USING A DISULFIDE BOND

Template:ABSTRACT PUBMED 11982362

About this Structure

Full experimental information is available from OCA.

Reference

Design and construction of an open multistranded beta-sheet polypeptide stabilized by a disulfide bridge., Venkatraman J, Nagana Gowda GA, Balaram P, J Am Chem Soc. 2002 May 8;124(18):4987-94. PMID:11982362

Page seeded by OCA on Mon Jul 28 08:07:36 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1jy4"
Personal tools