2chn

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:2chn.gif|left|200px]]
+
{{Seed}}
 +
[[Image:2chn.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2chn| PDB=2chn | SCENE= }}
{{STRUCTURE_2chn| PDB=2chn | SCENE= }}
-
'''BACTEROIDES THETAIOTAOMICRON HEXOSAMINIDASE WITH O-GLCNACASE ACTIVITY- NAG-THIAZOLINE COMPLEX'''
+
===BACTEROIDES THETAIOTAOMICRON HEXOSAMINIDASE WITH O-GLCNACASE ACTIVITY- NAG-THIAZOLINE COMPLEX===
-
==Overview==
+
<!--
-
O-GlcNAc is an abundant post-translational modification of serine and threonine residues of nucleocytoplasmic proteins. This modification, found only within higher eukaryotes, is a dynamic modification that is often reciprocal to phosphorylation. In a manner analogous to phosphatases, a glycoside hydrolase termed O-GlcNAcase cleaves O-GlcNAc from modified proteins. Enzymes with high sequence similarity to human O-GlcNAcase are also found in human pathogens and symbionts. We report the three-dimensional structure of O-GlcNAcase from the human gut symbiont Bacteroides thetaiotaomicron both in its native form and in complex with a mimic of the reaction intermediate. Mutagenesis and kinetics studies show that the bacterial enzyme, very similarly to its human counterpart, operates via an unusual 'substrate-assisted' catalytic mechanism, which will inform the rational design of enzyme inhibitors.
+
The line below this paragraph, {{ABSTRACT_PUBMED_16565725}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 16565725 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_16565725}}
==About this Structure==
==About this Structure==
Line 35: Line 39:
[[Category: N-acetylglucosamibe]]
[[Category: N-acetylglucosamibe]]
[[Category: O-glcnacase]]
[[Category: O-glcnacase]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 22:09:37 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 08:09:12 2008''

Revision as of 05:09, 28 July 2008

Image:2chn.png

Template:STRUCTURE 2chn

BACTEROIDES THETAIOTAOMICRON HEXOSAMINIDASE WITH O-GLCNACASE ACTIVITY- NAG-THIAZOLINE COMPLEX

Template:ABSTRACT PUBMED 16565725

About this Structure

2CHN is a Protein complex structure of sequences from Bacteroides thetaiotaomicron. Full crystallographic information is available from OCA.

Reference

Structure and mechanism of a bacterial beta-glucosaminidase having O-GlcNAcase activity., Dennis RJ, Taylor EJ, Macauley MS, Stubbs KA, Turkenburg JP, Hart SJ, Black GN, Vocadlo DJ, Davies GJ, Nat Struct Mol Biol. 2006 Apr;13(4):365-71. Epub 2006 Mar 26. PMID:16565725

Page seeded by OCA on Mon Jul 28 08:09:12 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2chn"
Personal tools