1qqd

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{{Seed}}
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{{STRUCTURE_1qqd| PDB=1qqd | SCENE= }}
{{STRUCTURE_1qqd| PDB=1qqd | SCENE= }}
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'''CRYSTAL STRUCTURE OF HLA-CW4, A LIGAND FOR THE KIR2D NATURAL KILLER CELL INHIBITORY RECEPTOR'''
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===CRYSTAL STRUCTURE OF HLA-CW4, A LIGAND FOR THE KIR2D NATURAL KILLER CELL INHIBITORY RECEPTOR===
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==Overview==
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The crystal structure of the human class I major histocompatibility complex molecule, human histocompatibility leukocyte antigen (HLA)-Cw4, the ligand for a natural killer (NK) cell inhibitory receptor, has been determined, complexed with a nonameric consensus peptide (QYDDAVYKL). Relative to HLA-A2, the peptide binding groove is widened around the COOH terminus of the alpha 1 helix, which contains residues that determine the specificity of HLA-Cw4 for the inhibitory NK receptor, KIR2D. The structure reveals an unusual pattern of internal hydrogen bonding among peptide residues. The peptide is anchored in four specificity pockets in the cleft and secured by extensive hydrogen bonds between the peptide main chain and the cleft. The surface of HLA-Cw4 has electrostatic complementarity to the surface of the NK cell inhibitory receptor KIR2D.
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(as it appears on PubMed at http://www.pubmed.gov), where 10429675 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10429675}}
==About this Structure==
==About this Structure==
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[[Category: Alpha helix]]
[[Category: Alpha helix]]
[[Category: Beta sheet]]
[[Category: Beta sheet]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:35:01 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 08:10:55 2008''

Revision as of 05:10, 28 July 2008

Image:1qqd.png

Template:STRUCTURE 1qqd

CRYSTAL STRUCTURE OF HLA-CW4, A LIGAND FOR THE KIR2D NATURAL KILLER CELL INHIBITORY RECEPTOR

Template:ABSTRACT PUBMED 10429675

About this Structure

1QQD is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of human histocompatibility leukocyte antigen (HLA)-Cw4, a ligand for the KIR2D natural killer cell inhibitory receptor., Fan QR, Wiley DC, J Exp Med. 1999 Jul 5;190(1):113-23. PMID:10429675

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