1ik0

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{{STRUCTURE_1ik0| PDB=1ik0 | SCENE= }}
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'''Solution Structure of Human IL-13'''
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===Solution Structure of Human IL-13===
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==Overview==
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Interleukin-13 has been implicated as a key factor in asthma, allergy, atopy and inflammatory response, establishing the protein as a valuable therapeutic target. The high-resolution solution structure of human IL-13 has been determined by multidimensional NMR. The resulting structure is consistent with previous short-chain left-handed four-helix bundles, where a significant similarity in the folding topology between IL-13 and IL-4 was observed. IL-13 shares a significant overlap in biological function with IL-4, a result of the common alpha chain component (IL-4Ralpha) in their respective receptors. Based on the available structural and mutational data, an IL-13/IL-4Ralpha model and a sequential mechanism for forming the signaling heterodimer is proposed for IL-13.
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{{ABSTRACT_PUBMED_11419948}}
==About this Structure==
==About this Structure==
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1IK0 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IK0 OCA].
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1IK0 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IK0 OCA].
==Reference==
==Reference==
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[[Category: Wilhelm, J.]]
[[Category: Wilhelm, J.]]
[[Category: Left-handed four-helix bundle]]
[[Category: Left-handed four-helix bundle]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 08:12:43 2008''

Revision as of 05:12, 28 July 2008

Image:1ik0.png

Template:STRUCTURE 1ik0

Solution Structure of Human IL-13

Template:ABSTRACT PUBMED 11419948

About this Structure

1IK0 is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Solution structure of human IL-13 and implication for receptor binding., Moy FJ, Diblasio E, Wilhelm J, Powers R, J Mol Biol. 2001 Jun 29;310(1):219-30. PMID:11419948

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