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1m0j
From Proteopedia
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(New page: 200px<br /><applet load="1m0j" size="450" color="white" frame="true" align="right" spinBox="true" caption="1m0j" /> '''solution structure of the beta domain of mt_...)
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Revision as of 18:54, 20 November 2007
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solution structure of the beta domain of mt_nc
Overview
The structure of [113Cd(7)]-metallothionein (MT_nc) of the Antarctic fish, Notothenia coriiceps, the first three-dimensional structure of a fish, metallothionein, was determined by homonuclear 1H NMR experiments and, heteronuclear [1H, 113Cd]-correlation spectroscopy. MT_nc is composed of, an N-terminal beta domain with 9 cysteines and 3 metal ions and a, carboxy-terminal alpha-domain with 11 cysteines and 4 metal ions. The, position of the ninth Cys of the alpha domain of MT_nc is different from, the corresponding Cys of mammalian MTs. As a result, the last CXCC motif, in the mammalian MT sequence becomes CXXXCC in the fish MT. This, difference leads to a structural change of the alpha domain and, in turn, to a different charge distribution with respect to that observed in, mammalian metallothioneins.
About this Structure
1M0J is a Single protein structure of sequence from Notothenia coriiceps with CD as ligand. Full crystallographic information is available from OCA.
Reference
Solution structure of MT_nc, a novel metallothionein from the Antarctic fish Notothenia coriiceps., Capasso C, Carginale V, Crescenzi O, Di Maro D, Parisi E, Spadaccini R, Temussi PA, Structure. 2003 Apr;11(4):435-43. PMID:12679021
Page seeded by OCA on Tue Nov 20 21:02:12 2007
