1oy6

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{{STRUCTURE_1oy6| PDB=1oy6 | SCENE= }}
{{STRUCTURE_1oy6| PDB=1oy6 | SCENE= }}
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'''Structural Basis of the Multiple Binding Capacity of the AcrB Multidrug Efflux Pump'''
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===Structural Basis of the Multiple Binding Capacity of the AcrB Multidrug Efflux Pump===
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==Overview==
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Multidrug efflux pumps cause serious problems in cancer chemotherapy and treatment of bacterial infections. Yet high-resolution structures of ligand transporter complexes have previously been unavailable. We obtained x-ray crystallographic structures of the trimeric AcrB pump from Escherichia coli with four structurally diverse ligands. The structures show that three molecules of ligands bind simultaneously to the extremely large central cavity of 5000 cubic angstroms, primarily by hydrophobic, aromatic stacking and van der Waals interactions. Each ligand uses a slightly different subset of AcrB residues for binding. The bound ligand molecules often interact with each other, stabilizing the binding.
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{{ABSTRACT_PUBMED_12738864}}
==About this Structure==
==About this Structure==
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[[Category: Zgurskaya, H I.]]
[[Category: Zgurskaya, H I.]]
[[Category: Membrane protein]]
[[Category: Membrane protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 08:13:59 2008''

Revision as of 05:14, 28 July 2008

Image:1oy6.png

Template:STRUCTURE 1oy6

Structural Basis of the Multiple Binding Capacity of the AcrB Multidrug Efflux Pump

Template:ABSTRACT PUBMED 12738864

About this Structure

1OY6 is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Structural basis of multiple drug-binding capacity of the AcrB multidrug efflux pump., Yu EW, McDermott G, Zgurskaya HI, Nikaido H, Koshland DE Jr, Science. 2003 May 9;300(5621):976-80. PMID:12738864

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