2bcj

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[[Image:2bcj.gif|left|200px]]
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{{STRUCTURE_2bcj| PDB=2bcj | SCENE= }}
{{STRUCTURE_2bcj| PDB=2bcj | SCENE= }}
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'''Crystal Structure of G Protein-Coupled Receptor Kinase 2 in Complex with Galpha-q and Gbetagamma Subunits'''
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===Crystal Structure of G Protein-Coupled Receptor Kinase 2 in Complex with Galpha-q and Gbetagamma Subunits===
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==Overview==
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G protein-coupled receptor kinase 2 (GRK2) plays a key role in the desensitization of G protein-coupled receptor signaling by phosphorylating activated heptahelical receptors and by sequestering heterotrimeric G proteins. We report the atomic structure of GRK2 in complex with Galphaq and Gbetagamma, in which the activated Galpha subunit of Gq is fully dissociated from Gbetagamma and dramatically reoriented from its position in the inactive Galphabetagamma heterotrimer. Galphaq forms an effector-like interaction with the GRK2 regulator of G protein signaling (RGS) homology domain that is distinct from and does not overlap with that used to bind RGS proteins such as RGS4.
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(as it appears on PubMed at http://www.pubmed.gov), where 16339447 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16339447}}
==About this Structure==
==About this Structure==
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[[Category: Rgs domain]]
[[Category: Rgs domain]]
[[Category: Wd40 protein]]
[[Category: Wd40 protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 20:06:47 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 08:18:20 2008''

Revision as of 05:18, 28 July 2008

Image:2bcj.png

Template:STRUCTURE 2bcj

Crystal Structure of G Protein-Coupled Receptor Kinase 2 in Complex with Galpha-q and Gbetagamma Subunits

Template:ABSTRACT PUBMED 16339447

About this Structure

2BCJ is a Protein complex structure of sequences from Bos taurus and Rattus norvegicus,mus musculus. Full crystallographic information is available from OCA.

Reference

Snapshot of activated G proteins at the membrane: the Galphaq-GRK2-Gbetagamma complex., Tesmer VM, Kawano T, Shankaranarayanan A, Kozasa T, Tesmer JJ, Science. 2005 Dec 9;310(5754):1686-90. PMID:16339447

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