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1yjo

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[[Image:1yjo.gif|left|200px]]
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{{STRUCTURE_1yjo| PDB=1yjo | SCENE= }}
{{STRUCTURE_1yjo| PDB=1yjo | SCENE= }}
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'''Structure of NNQQNY from yeast prion Sup35 with zinc acetate'''
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===Structure of NNQQNY from yeast prion Sup35 with zinc acetate===
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==Overview==
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Numerous soluble proteins convert to insoluble amyloid-like fibrils that have common properties. Amyloid fibrils are associated with fatal diseases such as Alzheimer's, and amyloid-like fibrils can be formed in vitro. For the yeast protein Sup35, conversion to amyloid-like fibrils is associated with a transmissible infection akin to that caused by mammalian prions. A seven-residue peptide segment from Sup35 forms amyloid-like fibrils and closely related microcrystals, from which we have determined the atomic structure of the cross-beta spine. It is a double beta-sheet, with each sheet formed from parallel segments stacked in register. Side chains protruding from the two sheets form a dry, tightly self-complementing steric zipper, bonding the sheets. Within each sheet, every segment is bound to its two neighbouring segments through stacks of both backbone and side-chain hydrogen bonds. The structure illuminates the stability of amyloid fibrils, their self-seeding characteristic and their tendency to form polymorphic structures.
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(as it appears on PubMed at http://www.pubmed.gov), where 15944695 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15944695}}
==About this Structure==
==About this Structure==
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[[Category: Keywords beta sheet]]
[[Category: Keywords beta sheet]]
[[Category: Steric zipper]]
[[Category: Steric zipper]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 16:24:23 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 08:19:04 2008''

Revision as of 05:19, 28 July 2008

Image:1yjo.png

Template:STRUCTURE 1yjo

Structure of NNQQNY from yeast prion Sup35 with zinc acetate

Template:ABSTRACT PUBMED 15944695

About this Structure

1YJO is a Single protein structure. Full crystallographic information is available from OCA.

Reference

Structure of the cross-beta spine of amyloid-like fibrils., Nelson R, Sawaya MR, Balbirnie M, Madsen AO, Riekel C, Grothe R, Eisenberg D, Nature. 2005 Jun 9;435(7043):773-8. PMID:15944695

Page seeded by OCA on Mon Jul 28 08:19:04 2008

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