2r7g

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:2r7g.gif|left|200px]]
+
{{Seed}}
 +
[[Image:2r7g.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2r7g| PDB=2r7g | SCENE= }}
{{STRUCTURE_2r7g| PDB=2r7g | SCENE= }}
-
'''Structure of the retinoblastoma protein pocket domain in complex with adenovirus E1A CR1 domain'''
+
===Structure of the retinoblastoma protein pocket domain in complex with adenovirus E1A CR1 domain===
-
==Overview==
+
<!--
-
The adenovirus (Ad) E1A (Ad-E1A) oncoprotein mediates cell transformation, in part, by displacing E2F transcription factors from the retinoblastoma protein (pRb) tumor suppressor. In this study we determined the crystal structure of the pRb pocket domain in complex with conserved region 1 (CR1) of Ad5-E1A. The structure and accompanying biochemical studies reveal that E1A-CR1 binds at the interface of the A and B cyclin folds of the pRb pocket domain, and that both E1A-CR1 and the E2F transactivation domain use similar conserved nonpolar residues to engage overlapping sites on pRb, implicating a novel molecular mechanism for pRb inactivation by a viral oncoprotein.
+
The line below this paragraph, {{ABSTRACT_PUBMED_17974914}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 17974914 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_17974914}}
==Disease==
==Disease==
Line 33: Line 37:
[[Category: Retinoblastoma protein]]
[[Category: Retinoblastoma protein]]
[[Category: Transcription repressor]]
[[Category: Transcription repressor]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 16:23:11 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 08:19:44 2008''

Revision as of 05:19, 28 July 2008

Image:2r7g.png

Template:STRUCTURE 2r7g

Contents

Structure of the retinoblastoma protein pocket domain in complex with adenovirus E1A CR1 domain

Template:ABSTRACT PUBMED 17974914

Disease

Known disease associated with this structure: Bladder cancer OMIM:[180200], Osteosarcoma OMIM:[180200], Pinealoma with bilateral retinoblastoma OMIM:[180200], Retinoblastoma OMIM:[180200]

About this Structure

2R7G is a Protein complex structure of sequences from Homo sapiens and Human adenovirus 5. Full crystallographic information is available from OCA.

Reference

Structure of the retinoblastoma protein bound to adenovirus E1A reveals the molecular basis for viral oncoprotein inactivation of a tumor suppressor., Liu X, Marmorstein R, Genes Dev. 2007 Nov 1;21(21):2711-6. PMID:17974914

Page seeded by OCA on Mon Jul 28 08:19:44 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2r7g"
Personal tools