2dpx

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[[Image:2dpx.gif|left|200px]]
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{{STRUCTURE_2dpx| PDB=2dpx | SCENE= }}
{{STRUCTURE_2dpx| PDB=2dpx | SCENE= }}
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'''Crystal Structure of human Rad GTPase'''
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===Crystal Structure of human Rad GTPase===
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==Overview==
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Rad (Ras associated with diabetes) is an RGK-family small GTPase that is over-expressed in the skeletal muscle of humans with type II diabetes. Unlike other small GTPases, RGK family members including Rad lack several conserved residues in the GTPase domain. Here, we report the crystal structure of the GTPase domain of human Rad in the GDP-bound form at 1.8 A resolution. The structure revealed unexpected disordered structures of both switches I and II. We showed that the conformational flexibility of both switches is caused by non-conservative substitutions in the G2 and G3 motifs forming the switch cores together with other substitutions in the structural elements interacting with the switches. Glycine-rich sequences of the switches would also contribute to the flexibility. Switch I lacks the conserved phenylalanine that makes non-polar interactions with the guanine base in H-Ras. Instead, water-mediated hydrogen bonding interactions were observed in Rad. The GDP molecule is located at the same position as in H-Ras and adopts a similar conformation as that bound in H-Ras. This similarity seems to be endowed by the conserved hydrogen bonding interactions with the guanine base-recognition loops and the magnesium ion that has a typical octahedral coordination shell identical to that in H-Ras.
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The line below this paragraph, {{ABSTRACT_PUBMED_16866878}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 16866878 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16866878}}
==About this Structure==
==About this Structure==
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[[Category: Signal transduction]]
[[Category: Signal transduction]]
[[Category: Small-g]]
[[Category: Small-g]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 00:56:10 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 08:20:08 2008''

Revision as of 05:20, 28 July 2008

Image:2dpx.png

Template:STRUCTURE 2dpx

Crystal Structure of human Rad GTPase

Template:ABSTRACT PUBMED 16866878

About this Structure

2DPX is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of human Rad GTPase of the RGK-family., Yanuar A, Sakurai S, Kitano K, Hakoshima T, Genes Cells. 2006 Aug;11(8):961-8. PMID:16866878

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