2vrh

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{{Seed}}
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{{STRUCTURE_2vrh| PDB=2vrh | SCENE= }}
{{STRUCTURE_2vrh| PDB=2vrh | SCENE= }}
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'''STRUCTURE OF THE E. COLI TRIGGER FACTOR BOUND TO A TRANSLATING RIBOSOME'''
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===STRUCTURE OF THE E. COLI TRIGGER FACTOR BOUND TO A TRANSLATING RIBOSOME===
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==Overview==
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Ribosome-associated chaperone Trigger Factor (TF) initiates folding of newly synthesized proteins in bacteria. Here, we pinpoint by site-specific crosslinking the sequence of molecular interactions of Escherichia coli TF and nascent chains during translation. Furthermore, we provide the first full-length structure of TF associated with ribosome-nascent chain complexes by using cryo-electron microscopy. In its active state, TF arches over the ribosomal exit tunnel accepting nascent chains in a protective void. The growing nascent chain initially follows a predefined path through the entire interior of TF in an unfolded conformation, and even after folding into a domain it remains accommodated inside the protective cavity of ribosome-bound TF. The adaptability to accept nascent chains of different length and folding states may explain how TF is able to assist co-translational folding of all kinds of nascent polypeptides during ongoing synthesis. Moreover, we suggest a model of how TF's chaperoning function can be coordinated with the co-translational processing and membrane targeting of nascent polypeptides by other ribosome-associated factors.
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(as it appears on PubMed at http://www.pubmed.gov), where 18497744 is the PubMed ID number.
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{{ABSTRACT_PUBMED_18497744}}
==About this Structure==
==About this Structure==
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[[Category: Rrna-binding]]
[[Category: Rrna-binding]]
[[Category: Trigger factor]]
[[Category: Trigger factor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 18 12:05:56 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 08:20:26 2008''

Revision as of 05:20, 28 July 2008

Image:2vrh.png

Template:STRUCTURE 2vrh

STRUCTURE OF THE E. COLI TRIGGER FACTOR BOUND TO A TRANSLATING RIBOSOME

Template:ABSTRACT PUBMED 18497744

About this Structure

2VRH is a Protein complex structure of sequences from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Molecular mechanism and structure of Trigger Factor bound to the translating ribosome., Merz F, Boehringer D, Schaffitzel C, Preissler S, Hoffmann A, Maier T, Rutkowska A, Lozza J, Ban N, Bukau B, Deuerling E, EMBO J. 2008 Jun 4;27(11):1622-32. Epub 2008 May 22. PMID:18497744

Page seeded by OCA on Mon Jul 28 08:20:26 2008

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