1mvh

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{{STRUCTURE_1mvh| PDB=1mvh | SCENE= }}
{{STRUCTURE_1mvh| PDB=1mvh | SCENE= }}
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'''structure of the SET domain histone lysine methyltransferase Clr4'''
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===structure of the SET domain histone lysine methyltransferase Clr4===
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==Overview==
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Methylation of histone H3 lysine 9 is an important component of the 'histone code' for heterochromatic gene silencing. The SET domain-containing Clr4 protein, a close relative of Su(var)3-9 proteins in higher eukaryotes, specifically methylates lysine 9 of histone H3 and is essential for silencing in Schizosaccharomyces pombe. Here we report the 2.3 A resolution crystal structure of the catalytic domain of Clr4. The structure reveals an overall fold rich in beta-strands, a potential active site consisting of a SAM-binding pocket, and a connected groove that could accommodate the binding of the N-terminal tail of histone H3. The pre-SET motif contains a triangular zinc cluster coordinated by nine cysteines distant from the active site, whereas the post-SET region is largely flexible but proximal to the active site. The structure provides insights into the architecture of SET domain histone methyltransferases and establishes a paradigm for further characterization of the Clr4 family of epigenetic regulators.
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(as it appears on PubMed at http://www.pubmed.gov), where 12389037 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12389037}}
==About this Structure==
==About this Structure==
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[[Category: Lysine methyltransferase]]
[[Category: Lysine methyltransferase]]
[[Category: Set-domain]]
[[Category: Set-domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 01:46:03 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 08:20:59 2008''

Revision as of 05:21, 28 July 2008

Image:1mvh.png

Template:STRUCTURE 1mvh

structure of the SET domain histone lysine methyltransferase Clr4

Template:ABSTRACT PUBMED 12389037

About this Structure

1MVH is a Single protein structure of sequence from Schizosaccharomyces pombe. Full crystallographic information is available from OCA.

Reference

Structure of the SET domain histone lysine methyltransferase Clr4., Min J, Zhang X, Cheng X, Grewal SI, Xu RM, Nat Struct Biol. 2002 Nov;9(11):828-32. PMID:12389037

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