1t2v

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1t2v.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1t2v.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1t2v| PDB=1t2v | SCENE= }}
{{STRUCTURE_1t2v| PDB=1t2v | SCENE= }}
-
'''Structural basis of phospho-peptide recognition by the BRCT domain of BRCA1, structure with phosphopeptide'''
+
===Structural basis of phospho-peptide recognition by the BRCT domain of BRCA1, structure with phosphopeptide===
-
==Overview==
+
<!--
-
The BRCT repeats in BRCA1 are essential for its tumor suppressor activity and interact with phosphorylated protein targets containing the sequence pSer-X-X-Phe, where X indicates any residue. The structure of the tandem BRCA1 BRCT repeats bound to an optimized phosphopeptide reveals that the N-terminal repeat harbors a conserved BRCT phosphoserine-binding pocket, while the interface between the repeats forms a hydrophobic groove that recognizes the phenylalanine. Crystallographic and biochemical data suggest that the structural integrity of both binding sites is essential for peptide recognition. The diminished peptide-binding capacity observed for cancer-associated BRCA1-BRCT variants may explain the enhanced cancer risks associated with these mutations.
+
The line below this paragraph, {{ABSTRACT_PUBMED_15133503}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 15133503 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_15133503}}
==Disease==
==Disease==
Line 35: Line 39:
[[Category: Missense mutation]]
[[Category: Missense mutation]]
[[Category: Phosphopeptide]]
[[Category: Phosphopeptide]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 09:26:50 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 08:21:16 2008''

Revision as of 05:21, 28 July 2008

Image:1t2v.png

Template:STRUCTURE 1t2v

Contents

Structural basis of phospho-peptide recognition by the BRCT domain of BRCA1, structure with phosphopeptide

Template:ABSTRACT PUBMED 15133503

Disease

Known disease associated with this structure: Breast cancer-1 OMIM:[113705], Breast-ovarian cancer OMIM:[113705], Ovarian cancer OMIM:[113705], Papillary serous carcinoma of the peritoneum OMIM:[113705]

About this Structure

1T2V is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural basis of phosphopeptide recognition by the BRCT domain of BRCA1., Williams RS, Lee MS, Hau DD, Glover JN, Nat Struct Mol Biol. 2004 Jun;11(6):519-25. Epub 2004 May 9. PMID:15133503

Page seeded by OCA on Mon Jul 28 08:21:16 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1t2v"
Personal tools