2h14

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[[Image:2h14.gif|left|200px]]
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{{STRUCTURE_2h14| PDB=2h14 | SCENE= }}
{{STRUCTURE_2h14| PDB=2h14 | SCENE= }}
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'''Crystal of WDR5 (apo-form)'''
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===Crystal of WDR5 (apo-form)===
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==Overview==
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The WD40-repeat protein WDR5 is a conserved subunit of Trithorax (TRX) histone methyltransferase complexes. WDR5 has been reported to selectively bind dimethylated Lys4 (K4me2) in histone H3 to promote K4 trimethylation by TRX. To elucidate the basis of this binding specificity, we have determined the crystal structure of WDR5 bound to a histone H3 peptide bearing K4me2. The structure reveals that the N terminus of histone H3 binds as a 3(10)-helix in the central depression formed by the WD40 repeats. R2 in histone H3 is bound in the acidic channel in the protein's core, whereas K4me2 is solvent exposed and does not engage in direct interactions with WDR5. Functional studies confirm that WDR5 recognizes A1, R2 and T3 in histone H3 but has virtually identical affinities for the unmodified and mono-, di- and trimethylated forms of K4, demonstrating that it does not discriminate among different degrees of methylation of this residue.
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(as it appears on PubMed at http://www.pubmed.gov), where 16829960 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16829960}}
==About this Structure==
==About this Structure==
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[[Category: Mll]]
[[Category: Mll]]
[[Category: Wd-40 repeat]]
[[Category: Wd-40 repeat]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 05:44:39 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 08:21:40 2008''

Revision as of 05:21, 28 July 2008

Image:2h14.png

Template:STRUCTURE 2h14

Crystal of WDR5 (apo-form)

Template:ABSTRACT PUBMED 16829960

About this Structure

2H14 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Molecular recognition of histone H3 by the WD40 protein WDR5., Couture JF, Collazo E, Trievel RC, Nat Struct Mol Biol. 2006 Aug;13(8):698-703. Epub 2006 Jul 9. PMID:16829960

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