2f69

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[[Image:2f69.gif|left|200px]]
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{{Seed}}
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[[Image:2f69.png|left|200px]]
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{{STRUCTURE_2f69| PDB=2f69 | SCENE= }}
{{STRUCTURE_2f69| PDB=2f69 | SCENE= }}
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'''Ternary complex of SET7/9 bound to AdoHcy and a TAF10 peptide'''
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===Ternary complex of SET7/9 bound to AdoHcy and a TAF10 peptide===
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==Overview==
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Human SET7/9 is a protein lysine methyltransferase (PKMT) that methylates histone H3, the tumor suppressor p53 and the TBP-associated factor TAF10. To elucidate the determinants of its substrate specificity, we have solved the enzyme's structure bound to a TAF10 peptide and examined its ability to methylate histone H3, TAF10 and p53 substrates bearing either mutations or covalent modifications within their respective methylation sites. Collectively, our data reveal that SET7/9 recognizes a conserved K/R-S/T/A motif preceding the lysine substrate and has a propensity to bind aspartates and asparagines on the C-terminal side of the lysine target. We then used a sequence-based approach with this motif to identify novel substrates for this PKMT. Among the putative targets is TAF7, which is methylated at Lys5 by the enzyme in vitro. These results demonstrate the predictive value of the consensus motif in identifying novel substrates for SET7/9.
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The line below this paragraph, {{ABSTRACT_PUBMED_16415881}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 16415881 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16415881}}
==About this Structure==
==About this Structure==
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[[Category: Protein lysine methyltransferase]]
[[Category: Protein lysine methyltransferase]]
[[Category: Set domain]]
[[Category: Set domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 03:30:34 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 08:30:43 2008''

Revision as of 05:30, 28 July 2008

Image:2f69.png

Template:STRUCTURE 2f69

Ternary complex of SET7/9 bound to AdoHcy and a TAF10 peptide

Template:ABSTRACT PUBMED 16415881

About this Structure

2F69 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural basis for the methylation site specificity of SET7/9., Couture JF, Collazo E, Hauk G, Trievel RC, Nat Struct Mol Biol. 2006 Feb;13(2):140-6. Epub 2006 Jan 15. PMID:16415881

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