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1m2f
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(New page: 200px<br /><applet load="1m2f" size="450" color="white" frame="true" align="right" spinBox="true" caption="1m2f" /> '''Solution structure of the N-terminal domain ...)
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Revision as of 18:58, 20 November 2007
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Solution structure of the N-terminal domain of Synechococcus elongatus KaiA (KaiA135N); Family of 25 structures
Overview
In the cyanobacterium Synechococcus elongatus (PCC 7942) the proteins, KaiA, KaiB, and KaiC are required for circadian clock function. We deduced, a circadian clock function for KaiA from a combination of biochemical and, structural data. Both KaiA and its isolated carboxyl-terminal domain, (KaiA180C) stimulated KaiC autophosphorylation and facilitated attenuation, of KaiC autophosphorylation by KaiB. An amino-terminal domain (KaiA135N), had no function in the autophosphorylation assay. NMR structure, determination showed that KaiA135N is a pseudo-receiver domain. We propose, that this pseudo-receiver is a timing input-device that regulates KaiA, stimulation of KaiC autophosphorylation, which in turn is essential for, circadian timekeeping.
About this Structure
1M2F is a Single protein structure of sequence from Synechococcus elongatus. Full crystallographic information is available from OCA.
Reference
Structure and function from the circadian clock protein KaiA of Synechococcus elongatus: a potential clock input mechanism., Williams SB, Vakonakis I, Golden SS, LiWang AC, Proc Natl Acad Sci U S A. 2002 Nov 26;99(24):15357-62. Epub 2002 Nov 15. PMID:12438647
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