2qs6

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{{STRUCTURE_2qs6| PDB=2qs6 | SCENE= }}
{{STRUCTURE_2qs6| PDB=2qs6 | SCENE= }}
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'''Structure of a Hoogsteen antiparallel duplex with extra-helical thymines'''
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===Structure of a Hoogsteen antiparallel duplex with extra-helical thymines===
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==Overview==
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We present the crystal structure of the DNA duplex formed by d(ATATATCT). The crystals contain seven stacked antiparallel duplexes in the asymmetric unit with A.T Hoogsteen base pairs. The terminal CT sequences bend over so that the thymines enter the minor groove and form a hydrogen bond with thymine 2 of the complementary strand in the Hoogsteen duplex. Cytosines occupy extra-helical positions; they contribute to the crystal lattice through various kinds of interactions, including a unique CAA triplet. The presence of thymine in the minor groove apparently contributes to the stability of the DNA duplex in the Hoogsteen conformation. These observations open the way toward finding under what conditions the Hoogsteen duplex may be stabilized in vivo. The present crystal structure also confirms the tendency of A.T-rich oligonucleotides to crystallize as long helical stacks of duplexes.
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(as it appears on PubMed at http://www.pubmed.gov), where 18447354 is the PubMed ID number.
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{{ABSTRACT_PUBMED_18447354}}
==About this Structure==
==About this Structure==
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[[Category: Oligonucleotide]]
[[Category: Oligonucleotide]]
[[Category: Thymine]]
[[Category: Thymine]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 4 09:58:45 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 08:34:54 2008''

Revision as of 05:34, 28 July 2008

Image:2qs6.png

Template:STRUCTURE 2qs6

Structure of a Hoogsteen antiparallel duplex with extra-helical thymines

Template:ABSTRACT PUBMED 18447354

About this Structure

2QS6 is a Single protein structure. Full crystallographic information is available from OCA.

Reference

Stabilization by extra-helical thymines of a DNA duplex with Hoogsteen base pairs., Pous J, Urpi L, Subirana JA, Gouyette C, Navaza J, Campos JL, J Am Chem Soc. 2008 May 28;130(21):6755-60. Epub 2008 May 1. PMID:18447354

Page seeded by OCA on Mon Jul 28 08:34:54 2008

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