2hx6

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[[Image:2hx6.jpg|left|200px]]
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{{STRUCTURE_2hx6| PDB=2hx6 | SCENE= }}
{{STRUCTURE_2hx6| PDB=2hx6 | SCENE= }}
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'''Solution structure analysis of the phage T4 endoribonuclease RegB'''
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===Solution structure analysis of the phage T4 endoribonuclease RegB===
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==Overview==
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The RegB endoribonuclease participates in the bacteriophage T4 life cycle by favoring early messenger RNA breakdown. RegB specifically cleaves GGAG sequences found in intergenic regions, mainly in translation initiation sites. Its activity is very low but can be enhanced up to 100-fold by the ribosomal 30 S subunit or by ribosomal protein S1. RegB has no significant sequence homology to any known protein. Here we used NMR to solve the structure of RegB and map its interactions with two RNA substrates. We also generated a collection of mutants affected in RegB function. Our results show that, despite the absence of any sequence homology, RegB has structural similarities with two Escherichia coli ribonucleases involved in mRNA inactivation on translating ribosomes: YoeB and RelE. Although these ribonucleases have different catalytic sites, we propose that RegB is a new member of the RelE/YoeB structural and functional family of ribonucleases specialized in mRNA inactivation within the ribosome.
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{{ABSTRACT_PUBMED_17046813}}
==About this Structure==
==About this Structure==
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2HX6 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Enterobacteria_phage_t4 Enterobacteria phage t4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HX6 OCA].
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2HX6 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Enterobacteria_phage_t4 Enterobacteria phage t4]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HX6 OCA].
==Reference==
==Reference==
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[[Category: Uzan, M.]]
[[Category: Uzan, M.]]
[[Category: Alpha/beta fold]]
[[Category: Alpha/beta fold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 08:37:55 2008''

Revision as of 05:38, 28 July 2008

Image:2hx6.png

Template:STRUCTURE 2hx6

Solution structure analysis of the phage T4 endoribonuclease RegB

Template:ABSTRACT PUBMED 17046813

About this Structure

2HX6 is a Single protein structure of sequence from Enterobacteria phage t4. Full experimental information is available from OCA.

Reference

Structural and functional studies of RegB, a new member of a family of sequence-specific ribonucleases involved in mRNA inactivation on the ribosome., Odaert B, Saida F, Aliprandi P, Durand S, Crechet JB, Guerois R, Laalami S, Uzan M, Bontems F, J Biol Chem. 2007 Jan 19;282(3):2019-28. Epub 2006 Oct 17. PMID:17046813

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